Vascular dementia (VaD) and Alzheimer's disease (AD) are the
most common causes of dementia in the elderly. The aim of
this study was to investigate carotid atherosclerosis, serum
lipid profiles, and atherogenic hormone levels in
nondiabetic Japanese men with VaD or AD. Carotid artery intima-
media thickness (IMT) and plaque, serum lipid and
lipoprotein profiles, including low-density lipoprotein
(LDL) particle size, as well as insulin-like growth factor-I
(IGF-I, somatomedin C) and testosterone levels, were
determined in 34 patients with AD, 37 patients with VaD, and
63 healthy male controls.
Our results indicate that VaD is associated with atherogenic
dyslipidemia, in particular, small dense LDL and carotid
atherosclerosis, whereas AD is associated with
hyposomatomedinemia and hypogonadism rather than
atherosclerosis.
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