dietary iron deprivation / colitis

And what exactly are we to make of this, how does it relate
to any body of theory, to what practical use is it, and
toward what goal can it be applied? Without this information
it is but another random abstract plucked from the web, one
among thousands of such.

Unless of course if someone shoots some acid up your ass you
can try this approach.

Quoted message said:

Subject: Re: dietary iron deprivation / colitis
From: [email hidden]
Date: 4/7/2004 12:58 PM Mountain Daylight Time
Message-id: <[email hidden]>

And what exactly are we to make of this, how does it relate
to any body of theory, to what practical use is it, and
toward what goal can it be applied? Without this
information it is but another random abstract plucked from
the web, one among thousands of such.

Unless of course if someone shoots some acid up your ass
you can try this approach.

Take a fkg . hike ..

I .. told .. you .. don't fk with my posts you little .. fk
..

Int J Colorectal Dis. 2004 Apr 6 [Epub ahead of print]
Related Articles, Links

Effects of iron deprivation or chelation on DNA damage in
experimental colitis.

Barollo M, D'Inca R, Scarpa M, Medici V, Cardin R, Fries W,
Angriman I, Sturniolo GC.

Department of Surgical and Gastroenterological
Sciences, University of Padua, Via Giustiniani 2,
Italy, 35128, Padova.

BACKGROUND AND AIMS. In inflammatory bowel diseases iron
contributes to the formation of DNA adducts through the
production of hydroxyl radicals. The aim of our study was to
evaluate the effects of dietary or pharmacological iron
deprivation in an experimental model of colitis in the rat
and its potential protective effect against DNA damage.
METHODS. Colitis was induced in rats by intracolonic
instillation of dinitrobenzene sulphonic acid. Rats were
assigned to an iron-deprived diet or to desferrioxamine
preceding the induction of colitis. The severity of colitis
was assessed by the presence of bloody diarrhea, colonic
macroscopic damage score, body-weight variations and the
amount of DNA colonic adducts. Hepatic and colonic iron
concentrations were measured. RESULTS. Treated rats
experienced less diarrhea and did not lose weight in
comparison to untreated animals. The macroscopic damage
score was significantly reduced in the iron-deprived diet
for the 5-week group ( P=0.03). Liver and colonic iron
levels were significantly more reduced in the iron-deprived
groups than in the standard diet group ( P<0.03 and P<0.01
after a 3- and 5-week iron-deprived diet, respectively). DNA
adduct formation was significantly reduced in the groups
deprived of iron for 5 weeks ( P<0.001) or treated with
desferrioxamine ( P<0.01). CONCLUSIONS. The degree of
colitis caused by DNBS is macroscopically improved by
dietary iron deprivation and to a lesser extent by
pharmacological chelation; genomic damage is reduced by
dietary iron deprivation or chelation, and this may have
clinical implications on cancer prevention.

PMID: 15067556 [PubMed - as supplied by publisher]

------------------------------------------------------------
--------------
------

Who loves ya. Tom Jesus Was A Vegetarian!
jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

Aquired iron overload

Acquired iron overload occurs when one receives
repeated blood transfusions, is exposed to excessive
amounts of iron through supplementation, tobacco smoke
inhalation, alcohol consumption, exposure to some types
of asbestos, and consumption of an iron-rich diet
comprised mostly of red meat.

Secondary iron overload is related to a problem of red blood
cell production which causes the body to behave as if it
doesn't have enough iron. Examples of this type of iron
overload are: thalassemia and sideroblastic anemia.

Another disorder associated with excess iron is porphyria
cutanea tarda (PCT) a metabolic problem that is usually
diagnosed because of blisters and blood spots on the back-
side of the hands.

Undiagnosed, untreated iron overload, regardless of its
origin can lead to diabetes, arthritis, depression,
impotence, liver-gall bladder disease, complete liver
failure, heart attack and cancer. Getting the right
tests, early, is one way to prevent unnecessary organ
damage and disease.