iron might protect tumour cells

That would suggest that, while providing anti-tumour
activity, iron also contributes to erectile dysfunction by
inhibiting production of nitric oxide.

You pays your money, takes what you get.:-)

GT

"doe" <[email hidden]> wrote in message news:20040617103054.29586.00000190@mb-
m16.aol.com...

Quoted message said:

Clin Exp Immunol. 2004 Jul;137(1):109-16. Related
Articles, Links

Iron down-regulates macrophage anti-tumour activity by
blocking nitric

oxide

Quoted message said:

production.

Harhaji L, Vuckovic O, Miljkovic D, Stosic-Grujicic S,
Trajkovic V.

Department of Neurobiology and Immunology, Institute for
Biological

Research,

Quoted message said:

University of Belgrade, Belgrade, Serbia and Montenegro.

SUMMARY Although the inhibitory effect of iron on
macrophage production of tumoricidal free radical nitric
oxide (NO) has been reported, its possible influence on
macrophage anti-tumour activity has not been
established. In

the

Quoted message said:

present study, FeSO(4) markedly reduced IFN-gamma + LPS-
induced NO

synthesis in

Quoted message said:

mouse and rat macrophages. The effect of iron coincided
with the loss of macrophage cytotoxic activity against NO-
sensitive C6 rat astrocytoma and

L929

Quoted message said:

mouse fibrosarcoma cell lines, as measured by MTT assay
for cellular respiration and the crystal violet test for
cell viability. Tumour cell survival did not improve
further in the presence of FeSO(4) if macrophage

NO

Quoted message said:

release and cytotoxicity were already blocked by
aminoguanidine. In

accordance

Quoted message said:

with the results obtained with exogenous iron, cell
membrane permeable

iron

Quoted message said:

chelator o-phenanthroline enhanced both macrophage NO
release and

anti-tumour

Quoted message said:

activity. Iron also down-regulated NO production and
increased the

viability of

Quoted message said:

L929 fibrosarcoma cells stimulated with IFN-gamma + LPS in
the absence of macrophages. However, neither NO release
nor cell viability was affected

by

Quoted message said:

iron addition to cultures of the C6 astrocytoma cell line.
Iron was unable

to

Quoted message said:

prevent L929 and C6 cell death induced by the NO releasing
chemicals SNP

and

Quoted message said:

SIN-1, indicating that iron-mediated inhibition of NO
synthesis, rather

than

Quoted message said:

interference with its cytotoxic action, was responsible
for the protection

of

Quoted message said:

tumour cells. Collectively, these results indicate that
iron might protect tumour cells by reducing both
macrophage and tumour cell-derived NO

release.

Quoted message said:

PMID: 15196250 [PubMed - in process]

----------------------------------------------------------
----------------
------

Who loves ya. Tom Jesus Was A Vegetarian!
jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD
PEOPLE WALKING

pages.ivillage.comdeadpeoplewalkingOpen ↗

Quoted message said:

Subject: Re: iron might protect tumour cells
From: "GT" [email hidden]
Date: 6/17/2004 2:11 PM Mountain Daylight Time
Message-id: <[email hidden]>

That would suggest that, while providing anti-tumour
activity, iron also contributes to erectile dysfunction by
inhibiting production of nitric oxide.

Actually iron PROMOTES .. tumor activity .. Iron down-
regulates macrophage anti-tumour activity by blocking nitric
oxide production.

Quoted message said:

You pays your money, takes what you get.:-)

GT

"doe" <[email hidden]> wrote in message news:20040617103054.29586.00000190@mb-
m16.aol.com...

Quoted message said:

Clin Exp Immunol. 2004 Jul;137(1):109-16. Related
Articles, Links

Iron down-regulates macrophage anti-tumour activity by
blocking nitric

oxide

Quoted message said:

production.

Harhaji L, Vuckovic O, Miljkovic D, Stosic-Grujicic S,
Trajkovic V.

Department of Neurobiology and Immunology, Institute for
Biological

Research,

Quoted message said:

University of Belgrade, Belgrade, Serbia and Montenegro.

SUMMARY Although the inhibitory effect of iron on
macrophage production of tumoricidal free radical nitric
oxide (NO) has been reported, its possible influence on
macrophage anti-tumour activity has not been
established. In

the

Quoted message said:

present study, FeSO(4) markedly reduced IFN-gamma + LPS-
induced NO

synthesis in

Quoted message said:

mouse and rat macrophages. The effect of iron coincided
with the loss of macrophage cytotoxic activity against
NO-sensitive C6 rat astrocytoma and

L929

Quoted message said:

mouse fibrosarcoma cell lines, as measured by MTT assay
for cellular respiration and the crystal violet test for
cell viability. Tumour cell survival did not improve
further in the presence of FeSO(4) if macrophage

NO

Quoted message said:

release and cytotoxicity were already blocked by
aminoguanidine. In

accordance

Quoted message said:

with the results obtained with exogenous iron, cell
membrane permeable

iron

Quoted message said:

chelator o-phenanthroline enhanced both macrophage NO
release and

anti-tumour

Quoted message said:

activity. Iron also down-regulated NO production and
increased the

viability of

Quoted message said:

L929 fibrosarcoma cells stimulated with IFN-gamma + LPS
in the absence of macrophages. However, neither NO
release nor cell viability was affected

by

Quoted message said:

iron addition to cultures of the C6 astrocytoma cell
line. Iron was unable

to

Quoted message said:

prevent L929 and C6 cell death induced by the NO
releasing chemicals SNP

and

Quoted message said:

SIN-1, indicating that iron-mediated inhibition of NO
synthesis, rather

than

Quoted message said:

interference with its cytotoxic action, was responsible
for the protection

of

Quoted message said:

tumour cells. Collectively, these results indicate that
iron might protect tumour cells by reducing both
macrophage and tumour cell-derived NO

release.

Quoted message said:

PMID: 15196250 [PubMed - in process]

---------------------------------------------------------
-----------------
------

Who loves ya. Tom

Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗
Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗