Policosanal

On Tue, 15 Jun 2004 13:55:07 -0400, "Dee Randall"

deedoveyatshenteldotnet said:

life-enhancement.comarticle template.aspOpen ↗

Has anyone taken this product, Policosanal vs.

Policosanal interferes with platelet clumping, creating a
risk of interactions with blood-thinning drugs, which is why
I've not tried
it.

But apparently it can lower LDL and raise HDL (on
average 20% up or down) with less chance of side effects
than statins.

j.

On Tue, 15 Jun 2004 13:55:07 -0400, "Dee Randall"

deedoveyatshenteldotnet said:

life-enhancement.comarticle template.aspOpen ↗

Has anyone taken this product, Policosanal vs.

One other point:

The nutritional supplement industry is not regulated. So,
supplements can be made available quickly and inexpensively,
especially when compared to prescription drugs.
Unfortunately, unscrupulous manufacturers can offer lower-
quality, cheap supplements sometimes containing small
amounts (if any) of the active ingredient.

L.

On Tue, 15 Jun 2004 13:55:07 -0400, "Dee Randall"

deedoveyatshenteldotnet said:

life-enhancement.comarticle template.aspOpen ↗

Has anyone taken this product, Policosanal vs.

In spite of the claims made by those who sell it, my one
person, three month clinical trial showed no benefit from
policosanol. Even if you just want to try it, be sure to get
the version made from sugar cane wax. The others are not
what the trials showing benefit used.

In article <[email hidden]>,

(listener) said:

Policosanal interferes with platelet clumping, creating a
risk of interactions with blood-thinning drugs, which is
why I've not tried
it.

But apparently it can lower LDL and raise HDL (on average
20% up or down) with less chance of side effects than
statins.

L.

Seems like listener said it in fewer words for which I
am grateful.

...........................................................-
..............
1: Int J Clin Pharmacol Res. 1999;19(4):105-
2. Related Articles, Links Effects of policosanol and
pravastatin on lipid profile, platelet aggregation and
endothelemia in older hypercholesterolemic patients.
Castano G, Mas R, Arruzazabala ML, Noa M, Illnait J,
Fernandez JC, Molina V, Menendez A. Medical Surgical
Research Center, Havana, Cuba. [email hidden] This
randomized, double-blind study was undertaken to compare
the effects of policosanol and pravastatin administered
at 10 mg/day on lipid profile, platelet aggregation and
endothelemia in older patients with type II
hypercholesterolemia and high coronary risk. After 6
weeks on a lipid-lowering diet, patients with lowdensity
lipoprotein (LDL) cholesterol levels > 3.4 mmol/l were
randomized to receive, under double-blind conditions,
policosanol or pravastatin 10 mg tablets that were taken
with the evening meal for 8 weeks. Policosanol
significantly (p < 0.00001) lowered LDLcholesterol
(3.3%), total cholesterol (13.9%) and the ratios of LDL-cholesterol/high-
density lipoprotein (HDL)- cholesterol (28.3%) and total
cholesterol/HDLcholesterol
(4.4%). Pravastatin significantly (p < 0.00001) lowered LDL-
cholesterol (15.6%), total cholesterol
(5.8%) and the ratios (p < 0.0001) of LDLcholesterol/ HDL-
cholesterol (18.9%) and total cholesterol/HDL-
cholesterol (15.7%). Policosanol, but not pravastatin,
significantly increased (p < 0.001) levels of HDL-
cholesterol (18.4%) and reduced (p < 0.01)
triglycerides (14.1%). Policosanol was more effective
(p < .05) than pravastatin in inhibiting platelet
aggregation induced by all agonists and it
significantly reduced (p < .0001) platelet aggregation
induced by arachidonic acid at 1.5 and 3 mmol/l by
42.2% and 69.5%, respectively, platelet aggregation
induced by collagen 0.5 microgram/ml (p < 0.05) (16.6%)
and that induced by adenosine diphosphate 1 mumol/l (p
< 0.01) (20.3%). Pravastatin significantly reduced (p <
0.001) (27%) only platelet aggregation induced by
arachidonic acid 3 mmol/l. Both drugs significantly
decreased (p < 0.00001) endothelemia levels but final
values were significantly lower (p < 0.001) in the
policosanol than in the pravastatin group. Both
treatments were safe and well tolerated. Pravastatin
significantly (p < 0.01) increased serum levels of
alanine amine transferase but individual values
remained within normal. Two patients on pravastatin
discontinued the study because of adverse experiences
(myocardial infarction and jaundice, respectively). In
conclusion, the effects of policosanol (10 mg/day) on
lipid profile, platelet aggregation and endothelemia in
older patients with type II hypercholesterolemia and
high coronary risk are more favorable than those
induced by the same doses of pravastatin. Publication
Types: Clinical Trial Randomized Controlled Trial PMID:
10939028 [PubMed - indexed for MEDLINE] Display
Abstract Show: 20 Sort Send to Text

--
Garden in Zone 5 S Jersey USA Shade

"listener" <[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

On Tue, 15 Jun 2004 13:55:07 -0400, "Dee Randall"

deedoveyatshenteldotnet said:

life-life-Open ↗
enhancement.com/article_template.asp?ID=834

Has anyone taken this product, Policosanal vs.

Quoted message said:

Policosanal interferes with platelet clumping, creating a
risk of interactions with blood-thinning drugs, which is
why I've not tried
it.

But apparently it can lower LDL and raise HDL (on average
20% up or down) with less chance of side effects than
statins.

**********
"an average 20% UP or DOWN" !!!! Now that's quite a chance
to take. Doing my math, for 250, that's 50 added or
subtracted! Goodness.

"Oliver Costich" <[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

On Tue, 15 Jun 2004 13:55:07 -0400, "Dee Randall"

deedoveyatshenteldotnet said:

life-life-Open ↗
enhancement.com/article_template.asp?ID=834 Has anyone
taken this product, Policosanal vs.

Quoted message said:

In spite of the claims made by those who sell it, my one
person, three month clinical trial showed no benefit from
policosanol. Even if you just want to try it, be sure to
get the version made from sugar cane wax. The others are
not what the trials showing benefit used.

Thank you for your reply. I'm assuming that you took the
"version made from sugar cane wax," correct? thanks
again. Dee

On Tue, 15 Jun 2004 21:25:36 GMT, [email hidden] (listener)

Quoted message said:

On Tue, 15 Jun 2004 13:55:07 -0400, "Dee Randall"

deedoveyatshenteldotnet said:

life-life-Open ↗
enhancement.com/article_template.asp?ID=834

Has anyone taken this product, Policosanal vs.

One other point:

The nutritional supplement industry is not regulated. So,
supplements can be made available quickly and
inexpensively, especially when compared to prescription
drugs. Unfortunately, unscrupulous manufacturers can offer
lower-quality, cheap supplements sometimes containing small
amounts (if any) of the active ingredient.

L.

That´s a good point you made and you are right, Listener !!

Michael

Michael F. Poellot <[email hidden]> wrote in part:

Quoted message said:

On Tue, 15 Jun 2004 21:25:36 GMT, [email hidden]

(listener) said:

On Tue, 15 Jun 2004 13:55:07 -0400, "Dee Randall"

deedoveyatshenteldotnet said:

life-life-Open ↗
enhancement.com/article_template.asp?ID=834

Has anyone taken this product, Policosanal vs.

One other point:

The nutritional supplement industry is not regulated. So,
supplements can be made available quickly and
inexpensively, especially when compared to prescription
drugs. Unfortunately, unscrupulous manufacturers can offer
lower-quality, cheap supplements sometimes containing
small amounts (if any) of the active ingredient.

L.

That´s a good point you made and you are right, Listener !!

Michael

Whether Listener is right or not depends on the country of
manufacture.
--
Jim Chinnis Warrenton, Virginia, USA

I might comment that it is usually the manufacturer, or
encapsulator/pill maker, who is at fault with adulteration
of OTC food supplements. Typically, and as I have found from
personal experience, purchasing the raw materials either
from the production plant or in smaller quantities from a
repackager will greatly increase your ability to obtain the
pure unadulterated supplement (policosanol in this case).
Certificates of analysis or CFAs should accompany your
product when it arrives at your doorstep. The CFA should
also provide a tracking number to the original lot of
production. Although such a certificate is not a guarantee
of purity, it provides a means of quality not obtainable
from purchase off the shelf. It also approximates FDA
regulations imposed upon pharmaceutical industries. It is
quite possible for a supplement manufacturer to produce a
product that exceeds FDA regulatory statutes for
manufacture.

--
Winning against heart attack and stroke
sonoscore.comsonoscore.comOpen ↗

On Thu, 17 Jun 2004 13:37:33 -0400, "Dee Randall"

deedoveyatshenteldotnet said:

"Oliver Costich" <[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

On Tue, 15 Jun 2004 13:55:07 -0400, "Dee Randall"

deedoveyatshenteldotnet said:

life-life-Open ↗
enhancement.com/article_template.asp?ID=834 Has anyone
taken this product, Policosanal vs.

Quoted message said:

In spite of the claims made by those who sell it, my one
person, three month clinical trial showed no benefit from
policosanol. Even if you just want to try it, be sure to
get the version made from sugar cane wax. The others are
not what the trials showing benefit used.

Thank you for your reply. I'm assuming that you took the
"version made from sugar cane wax," correct? thanks
again. Dee

Quoted message said:

Yes I did. That's what was tested in the trials.