asthma / iron / acidosis

Discussion in 'Health and medical' started by Doe, Mar 7, 2004.

  1. Doe

    Doe Guest

    What relationship could? .. ph / acidosis have on the
    frequency / severity of asthma attacks?

    It has been shown and extensively used .. ph .. in the
    Intensive Care Unit .. in those with acute asthma attacks
    are 'treated' with injection of bicarbonate of soda.

    This is a 'base' / alkaline which in theory would raise the
    ph of the body 'back into' a state of .. normal.

    Would / could this ph change BE .. related .. to the fact
    of elevated iron levels recently shown to BE in children
    with asthma?

    http://tinyurl.com/yuwc7

    And HOW is this related to this study ?

    This study shows anaphylactic shock is related somehow TO
    the 'saturation' OF the iron complexes.

    http://tinyurl.com/2blnp

    So in those WITH iron excess .. as in the study below ..
    acidic conditions NOW allow for the 'spillage' of iron ..
    would / could the SAME occur in those with asthma?

    <<snip>> acidosis temporarily disrupts the capacity of
    transferrin to bind iron <<snip>>

    Diabetes. 1982 Dec;31(12):1109-14. Related Articles, Links

    A mechanism of susceptibility to mucormycosis in diabetic
    ketoacidosis: transferrin and iron availability.

    Artis WM, Fountain JA, Delcher HK, Jones HE.

    The defect in host defense that makes the diabetic
    ketoacidotic (DKA) patient susceptible to mucormycosis has
    not been identified. Sera from 10 DKA patients and three
    normal volunteers were tested for their capacity to support
    the in vitro growth of a common etiologic agent of
    mucormycosis, Rhizopus oryzae. After equilibration with room
    air none of the normal or DKA sera, each of which was now
    extremely alkaline, supported growth of R. oryzae. When the
    sera were placed in a CO2 atmosphere that permitted
    simulation of the in vivo clinical pH (normal 7.40 and DKA
    7.3-6.6), four of seven DKA sera supported profuse fungal
    growth. No growth occurred in normal serum. The three DKA
    sera that did not support fungal growth at pH less than or
    equal to 7.3 contained less iron (x = 13 micrograms/dl) than
    the four sera that supported profuse fungal growth (x = 69
    micrograms/dl). Increasing the iron content of iron-poor DKA
    serum that did not support R. oryzae growth allowed profuse
    growth at acidotic conditions but not at pH greater than or
    equal to 7.4. Simulated acidotic conditions (pH
    7.3-6.6) also decreased the iron-binding capacity of normal
    serum stepwise from 266 micrograms/dl to 0. Our data
    indicate that acidosis temporarily disrupts the capacity
    of transferrin to bind iron and suggest that this
    alteration abolishes an important host defense mechanism
    that permits growth of R. oryzae.

    PMID: 6816646 [PubMed - indexed for MEDLINE]

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