Cinnamon / insulin action / glucose intolerance

Comment:

The anthocyanidins are the colors in red and blue fruit like blueberries and cranberries. And
there's already a limited amount of evidence that these things influence glucose tolerance
positively. For example see the following study where insulin levels in type II diabetics were
basically halved by cranberry extract.

findarticles.comarticle.jhtmlOpen ↗

I'm told that OceanSpray already maintains a small unit which supplies sugar-free cranberry juice
(yow-- sour!) to a small but fanatical market of diabetics, who presumably pucker up but drink it
and swear by it.

The cinnamon results below are all along this line.

But if I had diabetes I'd be wolfing cranberry extract.

SBH

[email hidden] (doe) wrote in message news:<[email hidden]>...

Quoted message said:

J Agric Food Chem. 2004 Jan 14;52(1):65-70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------
------

Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

Comment:

Anthocyanidins are the colors in ripe berries like blueberries and cranberries. It's already known
that they positively influence glucose tolerance: for example see

findarticles.comarticle.jhtmlOpen ↗

Where insulin levels were halved (p < 0.05) by cranberry extract, as compared with placebo. I'm told
that OceanSpray maintains a small output of (yow-- sour!) sugar-free cranberry juice output for a
small group of puckered up diabetics who drink it and swear by it.

The cinnamon results are all along this line, but if I had diabetes I'd be eating cranberry
extract instead.

SBH

[email hidden] (doe) wrote in message news:<[email hidden]>...

Quoted message said:

J Agric Food Chem. 2004 Jan 14;52(1):65-70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher]

Comment:

Anthocyanidins are the colors in ripe berries like blueberries and cranberries. It's already known
that they positively influence glucose tolerance: for example see

findarticles.comarticle.jhtmlOpen ↗

Where insulin levels were halved by cranberry extract. I'm told that OceanSpray maintains a small
output of (yow-- sour!) sugar free cranberry juice output for a small group of puckered up diabetics
who drink it and swear by it.

The cinnamon results are all along this line, but if I had diabetes I'd be eating cranberry
extract instead.

SBH

[email hidden] (doe) wrote in message news:<[email hidden]>...

Quoted message said:

J Agric Food Chem. 2004 Jan 14;52(1):65-70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher] [email hidden] (doe) wrote in message
news:<[email hidden]>... J Agric Food Chem. 2004 Jan 14;52(1):65-
70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------
------

Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

Comment:

Anthocyanidins are the colors in ripe berries like blueberries and cranberries. It's already known
that they positively influence glucose tolerance: for example see

findarticles.comarticle.jhtmlOpen ↗

Where insulin levels were halved by cranberry extract. I'm told that OceanSpray maintains a small
output of (yow-- sour!) sugar free cranberry juice output for a small group of puckered up diabetics
who drink it and swear by it.

The cinnamon results are all along this line, but if I had diabetes I'd be eating cranberry
extract instead.

SBH

[email hidden] (doe) wrote in message news:<[email hidden]>...

Quoted message said:

J Agric Food Chem. 2004 Jan 14;52(1):65-70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher] [email hidden] (doe) wrote in message
news:<[email hidden]>... J Agric Food Chem. 2004 Jan 14;52(1):65-
70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------
------

Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

Comment:

Anthocyanidins are the colors in ripe berries like blueberries and cranberries. It's already known
that they positively influence glucose tolerance: for example see

findarticles.comarticle.jhtmlOpen ↗

Where insulin levels were halved by cranberry extract. I'm told that OceanSpray maintains a small
output of (yow-- sour!) sugar free cranberry juice output for a small group of puckered up diabetics
who drink it and swear by it.

The cinnamon results are all along this line, but if I had diabetes I'd be eating cranberry
extract instead.

SBH

[email hidden] (doe) wrote in message news:<[email hidden]>...

Quoted message said:

J Agric Food Chem. 2004 Jan 14;52(1):65-70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher] [email hidden] (doe) wrote in message
news:<[email hidden]>... J Agric Food Chem. 2004 Jan 14;52(1):65-
70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------
------

Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

Comment:

Anthocyanidins are the colors in ripe berries like blueberries and cranberries. It's already known
that they positively influence glucose tolerance: for example see

findarticles.comarticle.jhtmlOpen ↗

Where insulin levels were halved by cranberry extract. I'm told that OceanSpray maintains a small
output of (yow-- sour!) sugar free cranberry juice output for a small group of puckered up diabetics
who drink it and swear by it.

The cinnamon results are all along this line, but if I had diabetes I'd be eating cranberry
extract instead.

SBH

[email hidden] (doe) wrote in message news:<[email hidden]>...

Quoted message said:

J Agric Food Chem. 2004 Jan 14;52(1):65-70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher] [email hidden] (doe) wrote in message
news:<[email hidden]>... J Agric Food Chem. 2004 Jan 14;52(1):65-
70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------
------

Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

Comment:

Anthocyanidins are the colors in ripe berries like blueberries and cranberries. It's already known
that they positively influence glucose tolerance: for example see

findarticles.comarticle.jhtmlOpen ↗

Where insulin levels were halved by cranberry extract. I'm told that OceanSpray maintains a small
output of (yow-- sour!) sugar free cranberry juice output for a small group of puckered up diabetics
who drink it and swear by it.

The cinnamon results are all along this line, but if I had diabetes I'd be eating cranberry
extract instead.

SBH

[email hidden] (doe) wrote in message news:<[email hidden]>...

Quoted message said:

J Agric Food Chem. 2004 Jan 14;52(1):65-70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold
and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and
mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two
trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their
protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of
the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as
antioxidants, potentiate insulin action, and may be beneficial in the control of glucose
intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher]

Steve Harris said:

The cinnamon results are all along this line, but if I had diabetes I'd be eating cranberry
extract instead.

I heard you the first time. :-) Better clean your 'send' button.

seven identical posts spam shilling reported

On 10 Jan 2004 14:33:01 -0800, [email hidden] (Steve Harris

) said:

Comment:

The anthocyanidins are the colors in red and blue fruit like blueberries and cranberries. And
there's already a limited amount of evidence that these things influence glucose tolerance
positively. For example see the following study where insulin levels in type II diabetics were
basically halved by cranberry extract.

findarticles.comarticle.jhtmlOpen ↗

I'm told that OceanSpray already maintains a small unit which supplies sugar-free cranberry juice
(yow-- sour!) to a small but fanatical market of diabetics, who presumably pucker up but drink it
and swear by it.

The cinnamon results below are all along this line.

But if I had diabetes I'd be wolfing cranberry extract.

SBH

[email hidden] (doe) wrote in message news:<20040108090102.19889.00002167@mb-
m01.aol.com>...

Quoted message said:

J Agric Food Chem. 2004 Jan 14;52(1):65-70. Links

Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA,
ARS, Bldg 307C, Rm 223, Beltsville, Maryland 20705-2350, Nuclear Magnetic Resonance Laboratory,
ARS, USDA, Beltsville, Maryland 20705-2350, Food Composition Laboratory, Beltsville Human
Nutrition Research Center, USDA, ARS, Beltsville, Maryland 20705-2350, and Department of
Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California
93106-9610.

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence
that dietary factors are involved in its regulation and prevention. We have shown that extracts
from cinnamon enhance the activity of insulin. The objective of this study was to isolate and
characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or
possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol
polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-
fold and display antioxidant activity were isolated and characterized by nuclear magnetic
resonance and mass spectroscopy. The polymers were composed of monomeric units with a molecular
mass of 288. Two trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were
isolated. Their protonated molecular masses indicated that they are A type doubly linked
procyanidin oligomers of the catechins and/or epicatechins. These polyphenolic polymers found in
cinnamon may function as antioxidants, potentiate insulin action, and may be beneficial in the
control of glucose intolerance and diabetes.

PMID: 14709014 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------
------

Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

Ze Administrator <[email hidden]> wrote in message news:<[email hidden]>...

Quoted message said:

Steve Harris said:

The cinnamon results are all along this line, but if I had diabetes I'd be eating cranberry
extract instead.

I heard you the first time. :-) Better clean your 'send' button.

Appologies. The fault is with GoogleGroups, which I'm using for my Usenet access. This time they
kept giving me a "timed out cannot find page" message, when the message had actually been sent. So I
kept trying until I finally got a "posted" confirmation. But the service, as it turns out, had
actually been posting every copy, and without emailing me one, either. Because Google has a 3-9 hour
delay on seeing what you've posted, it's not obvious when you've done a duplicate post.

I'd erase the extras, but google doesn't give you that option, either. You get what you pay for.

SBH

A careful reading of the original article says cranberry did nothing, it was another berry that
produced the results mentioned.

Quoted message said:

Quoted message said:

example see the following study where insulin levels in type II diabetics were basically halved
by cranberry extract.

This would appear to be an alternative to Glucophage (at least for non-diabetics looking to
reduce insulin levels for health reasons). A few months or so ago the Life Extension Foundation
published studies showing that Glucophage (Metformin) mimiced the effects of calory restriction.
Glucophage is an insulin sensitizer. It looks like Cranberry extract does the same thing.

-Bruce

[email hidden] (Steve Harris [email hidden]) wrote in message news:<[email hidden]>...

Quoted message said:

Comment:

The anthocyanidins are the colors in red and blue fruit like blueberries and cranberries. And
there's already a limited amount of evidence that these things influence glucose tolerance
positively. For example see the following study where insulin levels in type II diabetics were
basically halved by cranberry extract.

This would appear to be an alternative to Glucophage (at least for non-diabetics looking to
reduce insulin levels for health reasons). A few months or so ago the Life Extension Foundation
published studies showing that Glucophage (Metformin) mimiced the effects of calory restriction.
Glucophage is an insulin sensitizer. It looks like Cranberry extract does the same thing.

-Bruce

<[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

A careful reading of the original article says cranberry did

nothing, it

Quoted message said:

was another berry that produced the results mentioned.

Quoted message said:

Quoted message said:

example see the following study where insulin levels in type II diabetics were basically halved
by cranberry extract.

This would appear to be an alternative to Glucophage (at least

for

Quoted message said:

Quoted message said:

non-diabetics looking to reduce insulin levels for health

reasons). A

Quoted message said:

Quoted message said:

few months or so ago the Life Extension Foundation published

studies

Quoted message said:

Quoted message said:

showing that Glucophage (Metformin) mimiced the effects of calory restriction. Glucophage is an
insulin sensitizer. It looks like Cranberry extract does the same thing.

-Bruce

For some reason I do not appear to have the original post that gave the link. (Maybe I
killfiled it?)

Anyway, the main benefit of eating all those purple and blue berries is the flavinoids in them,
which do some nice things for your eyes, skin and overall general health. Not forgetting the high
Vit C content in them, a powerful anti-oxident in it's own right. Then of course there's the low
carb and the high fibre content, and the fact that they just taste good too. All good reasons to
make berries a part of a diabetic's diet.

NTL, none of the ones I eat, (and I eat quite a variety), have done anything *directly* to reduce my
insulin resistance.

As for cranberries, I have been drinking cranberry juice for quite some time. It did nothing for the
diabetes either.

Mark, what was THE berry that did the "trick"? Something rare and exotic? I am rather skeptical
about the whole thing.

Annette

---
Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (grisoft.comgrisoft.comOpen ↗).
Version: 6.0.564 / Virus Database: 356 - Release Date: 20/01/04

Using the same subject line, do a search on googlegroups.

Quoted message said:

Could you please provide details concerning the initial article? (publication details, etc)

I've just joined the group, and I'm interested in similar bibliography/references/info, for a study
under way.

Any help is wellcome.

Thank you.

"Annette" <[email hidden]> wrote in message -"]news:[email hidden]-
berlin.de...

Quoted message said:

<[email hidden]> wrote in message "]news:[email hidden]...

Quoted message said:

A careful reading of the original article says cranberry did

nothing, it

Quoted message said:

was another berry that produced the results mentioned.

>> example see the following study where insulin levels in type II diabetics were basically
>> halved by cranberry extract.
>
> This would appear to be an alternative to Glucophage (at least

for

Quoted message said:

>non-diabetics looking to reduce insulin levels for health

reasons). A

Quoted message said:

>few months or so ago the Life Extension Foundation published

studies

Quoted message said:

>showing that Glucophage (Metformin) mimiced the effects of calory restriction. Glucophage is
>an insulin sensitizer. It looks like Cranberry extract does the same thing.
>
>-Bruce

For some reason I do not appear to have the original post that gave the link. (Maybe I
killfiled it?)

Anyway, the main benefit of eating all those purple and blue berries is the flavinoids in them,
which do some nice things for your eyes, skin and overall general health. Not forgetting the high
Vit C content in them, a powerful anti-oxident in it's own right. Then of course there's the low
carb and the high fibre content, and the fact that they just taste good too. All good reasons to
make berries a part of a diabetic's diet.

NTL, none of the ones I eat, (and I eat quite a variety), have done anything *directly* to reduce
my insulin resistance.

As for cranberries, I have been drinking cranberry juice for quite some time. It did nothing for
the diabetes either.

Mark, what was THE berry that did the "trick"? Something rare and exotic? I am rather skeptical
about the whole thing.

Annette

---
Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (grisoft.comgrisoft.comOpen ↗).
Version: 6.0.564 / Virus Database: 356 - Release Date: 20/01/04

Could you please provide details concerning the initial article? (publication details, etc)

I've just joined the group, and I'm interested in similar bibliography/references/info, for a study
under way.

Any help is wellcome.

Thank you.

"Annette" <[email hidden]> wrote in message -"]news:[email hidden]-
berlin.de...

Quoted message said:

<[email hidden]> wrote in message "]news:[email hidden]...

Quoted message said:

A careful reading of the original article says cranberry did

nothing, it

Quoted message said:

was another berry that produced the results mentioned.

Quoted message said:

> example see the following study where insulin levels in type II diabetics were basically
> halved by cranberry extract.

This would appear to be an alternative to Glucophage (at least

for

Quoted message said:

Quoted message said:

non-diabetics looking to reduce insulin levels for health

reasons). A

Quoted message said:

Quoted message said:

few months or so ago the Life Extension Foundation published

studies

Quoted message said:

Quoted message said:

showing that Glucophage (Metformin) mimiced the effects of calory restriction. Glucophage is an
insulin sensitizer. It looks like Cranberry extract does the same thing.

-Bruce

For some reason I do not appear to have the original post that gave the link. (Maybe I
killfiled it?)

Anyway, the main benefit of eating all those purple and blue berries is the flavinoids in them,
which do some nice things for your eyes, skin and overall general health. Not forgetting the high
Vit C content in them, a powerful anti-oxident in it's own right. Then of course there's the low
carb and the high fibre content, and the fact that they just taste good too. All good reasons to
make berries a part of a diabetic's diet.

NTL, none of the ones I eat, (and I eat quite a variety), have done anything *directly* to reduce
my insulin resistance.

As for cranberries, I have been drinking cranberry juice for quite some time. It did nothing for
the diabetes either.

Mark, what was THE berry that did the "trick"? Something rare and exotic? I am rather skeptical
about the whole thing.

Annette

---
Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (grisoft.comgrisoft.comOpen ↗).
Version: 6.0.564 / Virus Database: 356 - Release Date: 20/01/04

[email hidden] wrote in message news:<[email hidden]>...

Quoted message said:

A careful reading of the original article says cranberry did nothing, it was another berry that
produced the results mentioned.

Quoted message said:

Quoted message said:

example see the following study where insulin levels in type II diabetics were basically halved
by cranberry extract.

This would appear to be an alternative to Glucophage (at least for non-diabetics looking to
reduce insulin levels for health reasons). A few months or so ago the Life Extension
Foundation published studies showing that Glucophage (Metformin) mimiced the effects of calory
restriction. Glucophage is an insulin sensitizer. It looks like Cranberry extract does the
same thing.

A careful reading shows you are incorrect. See below, this is for the cranberry group. It reduced
insulin blood levels by half, i.e., increases your insulin sensitivity. This is exactly what
Glucophage does:

--------------------------------------------------------------------------

More than one-half of the subjects had good control of blood glucose levels (<7.0 mmol/l) at the
beginning of the study. No differences were found between the treatment groups in fasting serum
glucose, Hb[A.sub.1c], fructosamine, triglyceride, or HDL or LDL levels after 6 and 12 weeks.

Placebo subjects had higher insulin values throughout the study (160 [+ or -] 167 vs. 86 [+ or -]
51 pmol/l at week 12, P < 0.05).

Different effects might be seen in subjects with poor glucose control, individuals with type 1
diabetes, or people who use medications to control their type 2 diabetes.

-----------------------------------------------------------------------------

You may be refering to the line:

Quoted message said:

No differences were found between the treatment groups in fasting serum glucose, ...

This is to be expected. A fasting situation does not stress your glucose regulation system. You need
to be a Type I or a bad off type II to have bad fasting glucose, and the authors raise this issue.
Chokeberrys may indeed lower fasting blood glucose levels, but this may be a mixed blessing.

-Bruce [email hidden]

Without seeing the full article your conclusion can not be supported. Glucophage for a diabetic has
two major effects, it lowers liver output of glucose and decreases insulin resistence, which is
assumed is your "insulin sensitivity" below. Because the berry had no effect on glucose levels any
difference in insulin was not due to it transporting glucose into cells and thus lowering it as a
blood level. You also assume that before the study both groups had equal blood levels of insulin,
and we don't know when the insulin levels were measured in either group. The latter is very
important because it can vary widely during the day in a diabetic in responce to eating. We would
also need to know if diabetics most always, those in the defined group at least, have lower levels
compared to the non-diabetic population at the same schedule of drawing blood relative to meals.
Because the glucose and lipid related results in no way reflected the effect of Glucophage in the
diabetic and because of the above unknowns, your conclusions remain unsupported. For all we know,
the placebo increased insulin, the results as stated equally support that conclusion.

Quoted message said:

Quoted message said:

Quoted message said:

restriction. Glucophage is an insulin sensitizer. It looks like Cranberry extract does the same
thing.

A careful reading shows you are incorrect. See below, this is for the cranberry group. It reduced
insulin blood levels by half, i.e., increases your insulin sensitivity. This is exactly what
Glucophage does:

--------------------------------------------------------------------------

More than one-half of the subjects had good control of blood glucose levels (<7.0 mmol/l) at the
beginning of the study. No differences were found between the treatment groups in fasting serum
glucose, Hb[A.sub.1c], fructosamine, triglyceride, or HDL or LDL levels after 6 and 12 weeks.

Placebo subjects had higher insulin values throughout the study (160 [+ or -] 167 vs. 86 [+ or -]
51 pmol/l at week 12, P < 0.05).

Different effects might be seen in subjects with poor glucose control, individuals with type 1
diabetes, or people who use medications to control their type 2 diabetes.

-----------------------------------------------------------------------------

You may be refering to the line:

Quoted message said:

No differences were found between the treatment groups in fasting serum gluc

ose, ...

This is to be expected. A fasting situation does not stress your glucose regulation system. You
need to be a Type I or a bad off type II to have bad fasting glucose, and the authors raise this
issue. Chokeberrys may indeed lower fasting blood glucose levels, but this may be a mixed blessing.

-Bruce [email hidden]

[email hidden] wrote in message news:<[email hidden]>...

Quoted message said:

Without seeing the full article your conclusion can not be supported.

The conclusion was that cranberry increases insulin sensitivity, and the article (which is short but
does appear at the reference given) does indeed support that.

Quoted message said:

Glucophage for a diabetic has two major effects, it lowers liver output of glucose and decreases
insulin resistence, which is assumed is your "insulin sensitivity" below. Because the berry had no
effect on glucose levels any difference in insulin was not due to it transporting glucose into
cells and thus lowering it as a blood level.

No. Because there was no effect on glucose blood level, you cannot assume there was no difference in
cell transport or liver production. These things are independently regulated. Glucose flux into and
out of the blood may increase or decrease, and glucose blood levels may stay fixed.

"Insulin sensitivity" is DEFINED as the amount of circulating insulin needed to maintain a given
fasting blood glucose. Therefore, by definition, insulin sensitivity was changed in this study. No
further measurements are necessary.

Quoted message said:

You also assume that before the study both groups had equal blood levels of insulin, and we don't
know when the insulin levels were measured in either group. The latter is very important because
it can vary widely during the day in a diabetic in responce to eating.

Well, no kidding, but you need to trust that authors doing a study on diabetes know this basic fact,
in the same way you need to trust that Earth astronomers reporting an astronomical finding
remembered to correct for weather effects. If you seriously doubt that they didn't measure fasting
levels of target blood markers, write the author(s) at [email hidden] and ask. It's a
randomized study, but you can also ask the authors if they did indeed calculate a p value for their
initial pre-treatment insulin values between groups.

Quoted message said:

We would also need to know if diabetics most always, those in the defined group at least, have
lower levels compared to the non-diabetic population at the same schedule of drawing blood
relative to meals.

Have lower levels of what?

Quoted message said:

Because the glucose and lipid related results in no way reflected the effect of Glucophage in the
diabetic and because of the above unknowns, your conclusions remain unsupported.

He didn't say anything about lipids.

Quoted message said:

For all we know, the placebo increased insulin, the results as stated equally support that
conclusion.

That's a silly-ass comment, and now you're arguing like a lawyer. You certainly know nothing about
the placebo effect. FYI, in placebo controlled studies, so long as both groups get pills, then BOTH
groups (not just the "placebo group"😉 get identical "placebo effects." Therefore the one thing we DO
know is that the results reported cannot be due to "placebo increased insulin." Sheesh.

SBH

Here is the bottom line on cranberries and insulin levels and Glucophage
like activity. The berries displayed none of the drug effect related to
glucose levels, which means we can't say anything about insulin based on
that result. In the abstract we see:

and 12 weeks. Placebo subjects had higher insulin values throughout the study (160 [+ or -] 167
vs. 86 [+ or -] 51 pmol/l at week 12, P <

This is the entire "proof" by which a conclusion was made that cranberries work like the above med.
The berries displayed none of the glucose effects. The above equally supports that whatever was in
the placebo was responcibile, the red coloring?, for the greater insulin level for the time period.
The berries show none of the effects of the drug and the sole result related to insulin supports
equally well the oppisite of the conclusions forced unto very little information. We don't know the
insulin levels before the study and we don't know the usual differences in diabetic and non-
diabetics in insulin levels. In short, this is wild speculation and conclusions based on weak "cut
and paste" plucking use of abstract material.