I recently built up a Carbon Fiber bike...all 105/Ultegra.
ALL Parts are new 105 compact Crank, Ultegra chain, 105 rear der.
There is a grumbling sound while in Large front & small rear & 2 or 3 gears up with still large front...
This is not typical clicking or rubbing....I can only compare it to when your driving & you get to far over & hit the "rumble" strips......or droaning sound....deep vibration type sound.
I have not ridden it yet...so I don't know if this noise is just vibration resonating through the Carbon frame while in the stand.....or if it's a whole other issue. But it sounds like it's more than just vibration.
Please let me know if you have had similar issues..and what it might be.
Thanks