kids and diab

a t1 father has a higher chance of passing t1 to the child than a t1 mother has

both of them are only slightly over the chances of "normal" parents giving the child t1 diabetes

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<[email hidden]> wrote in message "]news:[email hidden]...

Quoted message said:

If I have Type I diabetes and have a kid, does the kid have a much greater chance of having it

Anon, The last theory I heard is that the tendency for T1 can be passed on to the kid. I believe
that there is some sort of trigger that makes one become T1. In my case, my great-grandfather was
T1. Then I got the flu when I was 14, and then I became T1. I had had the flu several times before,
but for whatever reason, the flu I got just before I became diabetic hit a trigger in me that
changed how my pancreas works. I've read too many stories about an event (such as an illness,
stressful situation, pregnancy) being followed closely with a T1 diagnoses to believe that there not
some sort of connection.

I don't know if this really answers your question, but I hope it helps. Steph

<[email hidden]> wrote in message "]news:[email hidden]...

Quoted message said:

If I have Type I diabetes and have a kid, does the kid have a much greater chance of having it

[email hidden] wrote in
:"]news:[email hidden]:

Quoted message said:

If I have Type I diabetes and have a kid, does the kid have a much greater chance of having it

The increase in risk of diabetes to the child depends on the exact circumstances.

RELATIONSHIP RISK General Population 0.4% Offspring of diabetic 5% Offspring of diabetic father 6.1%
Offspring of diabetic mother 2% Offspring of diabetic mother older than 25 at birth 1.1% younger
than 25 at birth 3.6%

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Charly Coughran [email hidden]

<[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

If I have Type I diabetes and have a kid, does the kid have a much greater chance of having it

Goats are as likely to become diabetic as any other air breather. Slightly more so if either of
their parents are goats (I mean diabetic:-))

My own son hasn't shown any sign of developing it though, and he's close to thirty now. We do test
him regularly just to be on the safe side.

Beav

Charley, I should have know that you could find some real numbers! : ) I've never seen that chart.
Thanks, Steph

"Charly Coughran" <[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

[email hidden] wrote in :"]news:[email hidden]:

Quoted message said:

If I have Type I diabetes and have a kid, does the kid have a much greater chance of having it

The increase in risk of diabetes to the child depends on the exact circumstances.

RELATIONSHIP RISK General Population 0.4% Offspring of diabetic 5% Offspring of diabetic father
6.1% Offspring of diabetic mother 2% Offspring of diabetic mother older than 25 at birth 1.1%
younger than 25 at birth 3.6%

--
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Charly Coughran [email hidden]

"Stephanie Kolban" <[email hidden]> wrote in
:"]news:[email hidden]:

Quoted message said:

Anon, The last theory I heard is that the tendency for T1 can be passed on to the kid. I believe
that there is some sort of trigger that makes one become T1. In my case, my great-grandfather was
T1. Then I got the flu when I was 14, and then I became T1. I had had the flu several times
before, but for whatever reason, the flu I got just before I became diabetic hit a trigger in me
that changed how my pancreas works. I've read too many stories about an event (such as an illness,
stressful situation, pregnancy) being followed closely with a T1 diagnoses to believe that there
not some sort of connection.

You need to be careful here. While the standard picture of the pathogenesis of diabetes is a pre-
existing genetic susceptibility followed by an environmental trigger, the likely hood of you
identifying the trigger in your case is small. There are several problems in identifying the
trigger, or in the more general case, triggers since there are probably a number of them.

First, take a look at figure 1 at endotext.orgdiabetesframe5.htmOpen ↗
This is a schematic representation of the standard model of type 1 autoimmune diabetes. The
curve is pancreatic beta cell mass, which is a metric for your ability to produce insulin, vs.
time from birth to full blown type 1 defined as 0 c-peptide production, which is a metric for
insulin production. You will see this figure reproduced in almost any discussion of the
pathogenesis of type 1.

Note that at time 0, i.e. birth, you have some beta cell mass. It continues to grow for some period
in youth, then reaches a stable amount. Then comes the precipitating event, the trigger. Beta cell
mass starts declining and when around 80% are no longer functioning you are no longer able to
maintain normal glucose values and you get diagnosed.

The first problem with finding the trigger is that the time between the precipitating event and
diagnosis is variable and can be surprisingly long. The destruction of the beta cells can take
months, years, or (in at least one report) more than a decade. We are fooled by the sudden onset of
symptoms which leads us to believe that the disease must have a rapid progression and look back to
the latest event that we might take for a trigger. Although people have been working very hard for
a long time, we are still in the position of having lots of candidate triggers, but very few
confirmed answers.

One trigger that we do know is congenital rubella. It increases your risk of type 1 diabetes by
around 50 fold. Rubella after birth, however, does not. Most candidate triggers have some studies
that show some correlation with diabetes, and some studies that show no correlation. One example is
an early halt to breast feeding. There was a big splash in the press a few years ago from a study
that showed a strong correlation between an early halt and diabetes. Since then a number of other
studies have been done with very mixed results. A meta analysis of all the available studies
concluded that early halt increases the risk from the random risk of 0.4% to 0.6%. A fifty percent
increase in risk compared to congenital rubella's fifty fold. The interaction between the triggers
and the genetics, which are also complex, is not understood.

A second problem is that illness and pregnancy trigger bodily mechanisms that result in an
increase in insulin resistance. That places more stress on pancreatic insulin production. If the
progression to overt diabetes is close to the point where normal blood glucose values cannot be
maintained, the extra stress can tip the balance. Once that line is crossed, bg levels start to
rise and the resulting hyperglycemia, in and of itself, is toxic to the beta cells. This is one of
the reasons that the onset of severe symptoms is often so rapid. Once you have crossed the line,
things speed up.

When this happens in pregnancy, we call it gestational diabetes. When this happen in a patient with
some illness or infection, we just call it the onset of frank diabetes. In both cases the diabetes
was "uncovered" rather than "caused" by the events.

--
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Charly Coughran [email hidden]

Beav <[email hidden]> wrote on Wed, 18 Feb 2004 21:36:46
-0000:

Quoted message said:

<[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

If I have Type I diabetes and have a kid, does the kid have a much greater chance of having it

Quoted message said:

Goats are as likely to become diabetic as any other air breather. Slightly more so if either of
their parents are goats (I mean diabetic:-))

Quoted message said:

My own son hasn't shown any sign of developing it though, and he's close to thirty now. We do test
him regularly just to be on the safe side.

And how exactly do you go about this testing? I mean, he'll be a vigorous young man in his physical
prime whilst you're, er, not quite so young as you once were. Presumably you get several of your
friends (including a doctor) concealed in your house and invite your son over for dinner, at which
point he is ambushed and trussed up. Then the doc tells him "Hey, don't worry, this won't hurt .....
much" and starts sticking things into him, accompanied by his agonized screams. A couple of hours
later, Doc has to admit, somewhat disappointed, "Pity, you're _still_ not diabetic, we'll have to
let you go!".

Quoted message said:

Beav

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"Alan Mackenzie" <[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

Beav <[email hidden]> wrote on Wed, 18 Feb 2004 21:36:46 -0000:

Quoted message said:

<[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

If I have Type I diabetes and have a kid, does the kid have a much greater chance of having it

Quoted message said:

Goats are as likely to become diabetic as any other air breather. Slightly more so if either of
their parents are goats (I mean diabetic:-))

Quoted message said:

My own son hasn't shown any sign of developing it though, and he's close to thirty now. We do
test him regularly just to be on the safe side.

And how exactly do you go about this testing?

He gets an A1c done every year and I occasionally stab him when he least expects it (like an hour
after him eating us out of house and home:-)

I mean, he'll be a

Quoted message said:

vigorous young man in his physical prime whilst you're, er, not quite so young as you once were.

But I can show him a clean pair of heels in the vigour stakes🙂

Presumably you get several of your friends

Quoted message said:

(including a doctor)

Two as it happens.

concealed in your house and invite your son over for

Quoted message said:

dinner, at which point he is ambushed and trussed up.

He was brought up by me, so he's learned the benefit of tanding still when I tell him too. No need
to truss him.

Then the doc tells

Quoted message said:

him "Hey, don't worry, this won't hurt ..... much" and starts sticking things into him,
accompanied by his agonized screams.

He's my son, screaming doesn't come into it. the DOCTOR screams if he hurts the boy-chic though.
(He's got lightning fast feet)

A couple of hours

Quoted message said:

later, Doc has to admit, somewhat disappointed, "Pity, you're _still_ not diabetic, we'll have to
let you go!".

That's about it.

Beav