Landmark studies in vitamin c



N

No Way

Guest
Glutathione is the master antioxidant that recycles Vitamin
C

Anth <[email protected]> wrote in message
news:[email protected]...
> http://www.saveyourheart.com/Nutritional%20Approach%20Ess-
> ay.html Anth
>
>

What is Glutathione? It is the body's essential health aid.
This small protein comprised of 3 amino acids, produced
naturally in the body, maintains the three critical
functions of (A)ntioxidation, (I)mmune system booster and
(D)etoxification. (A.I.D.)

Glutathione precursors in the body make cancer cells more
susceptible to chemotherapy and radiation, but make healthy
cells more resistant.

Every person's life depends on Glutathione. Without it, your
cells would disintegrate from unrestrained oxidation, your
body would have little resistance to bacteria, viruses and
cancer, and your liver would eventually shrivel up from the
accumulation of toxins. Your liver has the highest amount of
Glutathione in your body. Glutathione is a detoxifier
therefore it is only natural that it supports the liver's
function. Glutathione is not a common household word. Even
Doctors usually only have a vague idea about it. In the last
5 years there have been over 30,000 medical articles about
it. This scientific understanding will eventually become
common knowledge. When you search the Internet National
Library of Medicine, PubMed you will find over 53,000
references to Glutathione.

http://www4.ncbi.nlm.nih.gov/entrez/query.fcgi

Example: Targeted Search -> Glutathione [ALL] cancer
...find over 7,000 medical journals associating Glutathione
and cancer.

The Journal of Applied Physiology has about 145 articles
featuring Glutathione.

A very good booklet about it is available. The booklet is
called: Glutathione Its role in cancer & anticancer therapy.
Written by Doctor Jimmy Gutman MD, FACEP. Doctor Gutman
tours North America lecturing about this topic educating
other Doctors and medical communities. His position as Chief
Resident at Montreal General Hospital Emergency Department
is well documented.

Each and every cell in your body is responsible for it's own
supply of Glutathione, and must have the necessary raw
materials to make it. Glutathione is always in demand and is
rapidly consumed when we experience illness, fatigue, and
even exercise. Some well know causes of Glutathione
depletion are poor diet, caffeine, pollution, drugs,
radiation, stress, injury, trauma, burns and infection.
Glutathione levels also diminish as we age and many diseases
normally associated with aging have been linked to
Glutathione deficiency.

Researchers know the value of antioxidants in good health,
as well as the treatment of diseases involving oxidative
attack by free radicals. A new branch of medicine is Free
Radical Biology. Because all other antioxidants depend on
the presence of Glutathione to function properly, scientists
call it "The Master Antioxidant." This master antioxidant is
responsible for the normal functional limits of vitamin's C
& E, peroxide, and lipoic acid. Elevated Glutathione levels
enable the body to produce more white blood cells, the front
line defense of your immune system. Glutathione fights off
invading disease-causing afflictions. The effects of cancer
radiation and chemotherapy treatments are diminished by
raising your internal Glutathione levels. Glutathione plays
a central role in the functions of these immune cells. The
limiting factor in the proper activity of our lymphocytes
(white blood cells) is the availability of Glutathione.
Glutathione is 'food' for your immune system.

Glutathione is also for detoxification. Doctors and
toxicologists use Glutathione promoting drugs like NAC (N-
acetylcysteine), OTC (ornithine decarboxdecarboxylase
procysteine), OTZ (oxothiazolidine carboxylate) and
Procysteine to detoxify certain types of drug overdoses
including Tylenol. These drugs have serious side effects and
often contribute to Glutathione imbalance and depletion. Low
Glutathione levels in your liver causes more toxins to
circulate through your body resulting in damage to
individual cells and organs. Your liver has the highest
level of Glutathione in your body, and as we know the liver
is the detoxifier.

Some Natural ways to raise Glutathione levels have been
attempted.

Glutathione itself taken orally in pill or powder form is
not particularly helpful to the body. A small amount may
make it into the bloodstream but most gets lost in the
digestive process and cannot raise intracellular Glutathione
levels. It may even lead to a possible decrease in blood
Glutathione. Oral, Inhaled, Injected Glutathione and
Cysteine are both unstable and toxic. Cysteine (L Cysteine)
is toxic. Methionine contributes to hardening of the
arteries. Melatonin is under investigation as suspicious to
good health. Glutamine causes gastrointestinal upset, kidney
and liver concerns. Lipoic Acid is still under
investigation, Silymarin has liver concerns, gas, cramps,
and diarrhea. The Solution. Your body has to produce
(synthesize) Glutathione intracellularly.inside your cells.
It has been discovered that only one whey protein has the
key ingredients for natural Glutathione production. Most
whey powders including ones in health food stores and
nutritional supply stores vary in protein content. They have
protein breakdown, fat content, lactose content, milk from
cows subjected to antibiotics and steroids, pasteurization
to denature them and loose bioactivity. Common whey powders
are not bioactive, and do not act as Glutathione precursors.

An Undenatured Bioactive Whey Protein containing high levels
of non-denatured protein & Cysteine is the only natural way
to boost or increase your body's internal Glutathione level.

There is only one company in the world with such a product.
Immunotec Research Canada Limited. Product identification:
HMS-90 In Canada, Immunocal in the United States. Canada
will not allow the US name because it suggests that the
product has something to do with 'immune' benefits. The
Canadian name (HMS-90) is a contraction of Humanized Milk
Serum having 90% protein. The Canadian name might be more
interesting because it shows they are actually replicating
Mother's milk for anyone. Mother's milk has the same
ingredients and it is nature's way to boost the immune
system of a newborn.

Immunotec's Glutathione precursor is a Bioactive whey based
product having 90% protein and is steroid free, antibiotic
free, lactose free, fat free. They have invested 22 years of
research to complete the discovery of the product.

There has been over 10 Million dollars invested in
this research.

The scientific discoveries were supported by Medical Doctors
and Scientists and Grants from the Canadian Government and
the Canada Research Council.

Product development was done in laboratories at McGill
University in conjunction with Montreal Hospital, Montreal
Children's Hospital Research Institute, Jewish General
Hospital, Institute Pasteur Paris, France, Centre National
de la Recherche Scientifique Paris, France.

There are 23 Completed Clinical Studies in Humans. Therefore
they are beyond the discovery level.

Immunotec Research has been granted 10 International "Method-Of-
Use" patents including 5 for Cancer (chemotheric therapy)
and 2 patents for H.I.V. Two patents for boosting the immune
system. These are critical for cancer treatment, cancer
prevention and immune system compromised human health
concerns. The immune system patents also help H.I.V. and
cancer patients with energy loss, hair loss, and immune
system breakdown. The transition of H.I.V. to A.I.D.S. is
when the body has reached a Glutathione deficiency.

Immunocal is listed in the 2002 US Physician's Desk
Reference. Immunocal is the only natural product listed
in the 2002 US Pharmacy (Red) Book. Immunocal is the
only natural product covered by 2 major drug plans
(Medicare & Medicaid)

There are over 495 Medical Journal Listings about this
natural product at the National Library of Medicine "PubMed"
Med Line Internet Site.
http://www4.ncbi.nlm.nih.gov/entrez/query.fcgi Search ->
Immunocal -<

A search at www.google.com will find a few of the Doctors
involved in the medical science of this natural product.
Dr. Gustavo Bounous, Dr. Allen Somersall, Dr. Jimmy
Gutman, Dr. Jerome Waters, Dr. Roger Mazlen, Dr.
Robert I. Bender.

Gustavo Bounous MD, Immunotec's Director of Research and
Development, has had a distinguished academic career and has
co-authored numerous articles on proteins and the immune
system in major professional journals worldwide. After
completing his studies at the University of Turin in Italy,
he was awarded the 1965 medal of the Royal College of
Physicians and Surgeons. In 1968, he was named Career
Investigator of the Medical Research Council of Canada; a
post that he held for a period of 25 years. It was in 1978
that he initiated his studies on the discovery and
development of a dietary protein source from whey
concentrate; work that eventually led to the creation of HMS
90, Immunocal.

In April, 1998 Mr. Chuck Roberts, President of Immunotec
Research, testified before a select committee of Canadian
Parliament about Government regulations concerning the
marketing of natural food products, with perceived health
benefits, like HMS-90. It is an example of the new category
of nutriceuticals, as some in the industry call them. In
Canada there are only 2 recognized broad categories for
products normally ingested by mouth: foods and drugs. The
law is very prohibitive regarding any claims for 'food'
products and naturally demands much more justification,
specification, and regulation in the distribution and use of
'drugs.' The United States now recognizes the
'Nutriceutical' category. Immunotec made their presentation
with published data, scientific studies and with method of
use patents in hand. Only the future will determine when the
Canadian Government will allow the third category in Canada.
The encouraging part is when the press arrive at the
companies headquarters in Quebec seeking to expose
unconfirmed medical claims. Once the diligent journalists
see the published research reports from reputable medical
journals, see the credentials of the investigators, see
results of clinical trials and talk with Doctor Bounous and
Mr. Roberts, they leave with a new appreciation for a
serious company which understands that until the laws and
regulations are changed in Canada, it cannot legally make
medical claims about their natural 'food' product. Immunotec
Research had a marketing decision to make. There were
international drug companies negotiating for the
distribution rights to a product that qualified for cancer
and H.I.V. therapeutic treatment patents. During
negotiations senior drug company executives advised
Immunotec to find alternative methods of distribution. The
marketing and consumer costs of a 'drug' category would have
meant that the product cost for the average person would
have been too high. Dieter Beer who is an Immunotec Research
partner and marketing business expert was advised that
direct distribution would be a much better avenue. This
method of distribution has allowed the launch of HMS-90 4
years ago through a system of individuals and small
businesses who represent the companies best interests and
the distribution of information about the company and it's
products. This has proven to be a perfect solution to the
'drug', 'food' dilemma as it now exists. The result is
availability of a world class health maintenance product at
a very low cost. The ethical side of the Immunotec decision
is that the average person has access to a scientifically,
medically proven, health maintenance product at an
affordable cost. This is a saving to the existing Health
Care system because of a few factors. There is no Doctor
cost to prescribe the product. There is no cost to the
O.H.I.P. healthcare resources and funds. And the fact that
if people's Glutathione levels are elevated there will be
less sickness, diseases and health care costs. This would
also cost employers less sick day payouts. If people are
healthier, with less disease they will enjoy a higher
quality of life. Traditional drugs have harmful side effects
that a person's body has to deal with. To utilize something
that has no side effects and is completely complimentary to
conventional treatments from medical Doctors is an
intelligent choice for a Naturopathic Doctor to administer
and prescribe to their patients. Historically hospitals were
Naturopathic in the way they treated patients. In the past
200 years a change has happened. Drug companies have had a
major influence in the training of Doctors and the
operations of Hospitals. This has been a financial boom to
the drug company industries. History now shows us that
antibiotics are not working as well any more. 'Super' bugs
are now created due to immunity to antibiotics. Traditional
drugs are taxing to a person's immune system. People are
looking back to see if the 'old' days had any health
maintenance aspects being ignored today. Health food stores
are flourishing, alternative health solutions are being
published daily in newspapers. People are more informed by
what has happened in the past. They can learn what things
have caused health distress, sickness, etc. in the past. We
can discover information now on the Internet. Currently HMS-
90 is available in 10 gram packages and production can keep
up with the current sale demands. There are about 160,000
people per month using this product. This represents a large
group of people who are raising their Glutathione levels in
the quest for good health. There are no opposing
perspectives of the key stakeholders. Four out of the five
company executives came out of retirement to launch
Immunotec Research Limited. These stakeholders learned what
this product will do for people's health in a natural way
and they support it 100%. Skeptics will have to do their own
research about Glutathione. Many medical and scientific
discoveries in the past were not accepted until people were
given the tools and proofs needed to be educated.
Traditional Canadian hospitals and medical Doctors are
closely associated with Pharmaceutical drug companies. I
think that it would be very difficult for a natural product
to be endorsed and prescribed in Canadian hospitals. This
may change in the future. In the United States Medicare and
Medicaid drug plans reimburse the product and there are many
medical Doctors that prescribe it and many hospitals
encourage the use of it. The 'Nutriceutical' category in the
United States is the reason for this. One action option is
to have HMS-90 prescribed in hospitals by Doctors. This will
increase patient's chances of regaining health and
experiencing less adverse effects of traditional drugs. HMS-
90 is complimentary to current drug therapies. HMS-90 will
change how medicine is practiced today. Using this product
will decrease spending of hospital funds, Doctor resources
and medication costs. Alternative and medical doctors can
prescribe this product for their patients. It is just the
education process they must go through before realizing the
health potential and disease fighting process that happens
with elevated levels of Glutathione. If HMS-90 is endorsed
by the conventional medical fields patients may be confused
by the simplicity of the product. Patients will need
education and information about the product. People will
have to start thinking about prevention and be proactive
about their health instead of reacting to ongoing health and
sickness concerns. Some restrictions are given for
prescribing HMS-90. People who have a specific milk protein
allergies, those who are in kidney failure, and anyone on
immunosuppressive drugs or medications should not take this
product without medical supervision. This product is
available from a private Canadian company based in Quebec.
The distribution system they have chosen means there will be
no inflated product costs because of advertising,
warehousing, retail store costs and related traditional
marketing methods. The negative side of this is that
hospital patients and the general public will not be exposed
to it in traditional ways. Glutathione has an important role
to play in the treatment and prevention of hundreds of
diseases. Clinical tests show that raised Glutathione levels
may address some of the major health issues of our time.
Possible clinical applications of high body levels of
Glutathione include: Aging, Cardiovascular, Digestive,
Toxicology, Infectious disease & Immunology, Cancer,
Pulmonary and Metabolic health concerns, burns and many
injuries. Glutathione supplies the tools for the body to
fight off these threats naturally. An interesting fact is
that Alzheimer's & Parkinson's patients have very low
Glutathione levels in their bodies. At autopsy they are
found to be about 40% deficient in Glutathione according to
information from Doctor Jimmy Gutman. PubMed has about
95,000 completed studies published about Glutathione and
Alzheimer's & Parkinson's. Naturopathic Doctors act to
identify and remove obstacles to healing and recovery, and
to facilitate and increase this inherent self-healing
process. Naturopathic Doctors share information and
knowledge with their patients and encourage self-
responsibility for health. And to use methods and medicines
which minimize the risk of harmful side effects, using the
least force necessary to diagnose and treat. HMS-90 matches
the principals of the Naturopathic College and its mandate
to help people heal themselves naturally.

Listen to a video presented by Doctor Gutman about
Glutathione
http://www.immunotec.com/page.asp?intNodeID=10682

Please feel free to review these notable Internet sites
about Glutathione.
http://www.thorne.com/altmedrev/fulltext/glut.html
http://www.immunesystemsupport.com/wpcagmct/gmct.html http:-
//www.fda.gov/ohrms/dockets/ac/00/slides/3652s1_05/sld001.h-
tm
http://www.carb.nist.gov/gilliland_group/molecules/gst.html
http://micro.magnet.fsu.edu/aminoacids/pages/glutathione.ht-
ml http://www.aids.org/immunet/atn.nsf/page/ZQX26601.html

REFERENCES
1. Meister A. The antioxidant effects of Glutathione and
ascorbic acid. In: Oxidative Stress, Cell Activation and
Viral Infection. C. Pasquier et al (Eds.). Birkauser
Verlag, Basel, Switzerland, 101-11, 1994.
2. Meister A, Anderson ME. Glutathione. Ann Rev Biochem 52:
711-60, 1983.
3. Kaplowitz N, Aw TY, Ookhtens M. The regulation of
hepatic glutathione. Ann Rev Pharmacol Toxicol 25:
715-44, 1985.
4. Witschi A, Reddy S, Stofer B, Lauterburg BH. The
systemic availability of oral glutathione. Eur J Clin
Pharmacol 43: 667-9, 1992.
5. Meister A. New aspects of glutathione biochemistry and
transport selective alteration of glutathione
metabolism. Nutr Rev 42: 397-410, 1984.
6. Bounous G, Gold P. The biological activity of
undenatured dietary whey proteins: role of glutathione.
Clin Invest Med 14: 296-309, 1991.
7. Droege W, Eck HP, Mihm S, Galter D. Abnormal redox
regulation in HIV infection and other immunodeficiency
diseases. In: Oxidative Stress, Cell Activation and
Viral Infection. C. Pasquier et al (Eds). Birkauser
Verlag, Basel, Switzerland, 285-99, 1994.
8. Noelle RJ, Lawrence DA. Determination of glutathione in
lymphocytes and possible association of redox state and
proliferative capacity of lymphocytes. Biochem J 198:
571-9, 1981.
9. Fidelus RK, Tsan MF. Glutathione and lymphocyte
activation: A function of aging and auto-immune disease.
Immunology 61: 503-8, 1987.
10. Staal FJT, Roederer M, Israelski DM, Bubp J et al.
Intracellular glutathione levels in T cell subsets
decreases in HIV-infected individuals. AIDS Res and Hum
Retro- viruses 8: 305-11, 1992.
11. Herzenberg L, De Rosa S, Dubs G, Roederer M et al.
Glutathione deficiency is associated with impaired
survival in HIV disease. Proc Natl Acad Sci USA 94:
1967-72, 1997.
12. Bounous G, Stevenson MM, Kongshavn PAL. Influence of
dietary lactalbumin hydrolysate on the immune system of
mice and resistance to Salmonellosis. J Infect Dis 144:
281, 1981.
13. Bounous G, Kongshavn PAL. Influence of dietary proteins
on the immune system of mice. J Nutr 112: 1747-55, 1982.
14. Bounous G, Letourneau L, Kongshavn PAL. Influence of
dietary protein type on the immune system of mice. J
Nutr 113: 1415-21, 1983.
15. Bounous G, Kongshavn PAL. Influence of protein type in
nutritionally adequate diets on the development of
immunity. In: Absorption and Utilization of Amino Acids.
M. Friedman (Ed.). Boca Raton, Florida: CRC Press, vol.
2, 219-32, 1989.
16. Bounous G, Batist G, Gold P. Immunoenhancing property of
dietary whey protein in mice: role of glutathione. Clin
Invest Med 12: 154-61,1989.
17. Bounous G, Shenouda N, Kongshavn PAL, Osmond DG.
Mechanism of altered B-cell response induced by changes
in dietary protein type in mice. J Nutr
18: 1409-17, 1985.
19. Hirai R, Nakai S, Kikuishi H, Kawai K. Evaluation of the
Immunological Enhancement Activities of Immunocal.
Otsuka Pharmaceutical Co. Cellular Technology Institute,
Dec. 13, 1990.
20. Eigel WN, Butler JE, Ernstrom CA, Farrell HM et al.
Nomenclature of proteins of cow's milk. Fifth revision.
J Dairy Sci 67: 1599-631, 1984.
21. Goodman RE, Schanbacher FL. Bovine lactoferrin in RNA:
Sequence, analysis, and expression in the mammary gland.
Biochem Biophys Res Commun
22: 75-84, 1991.
23. Duncan B, Ey J, Holberg CJ, Wright AL et al. Exclusive
breast-feeding for at least 4 months protects against
otitis media. Paediatrics 91: 867-72, 1993.
24. Frank AL, Taber LN, Glezen WP, Kasel GL et al. Breast-
feeding and respiratory virus infection. Paediatrics 70:
239-45, 1982.
25. Mather G, Gupta N, Mathur S, Gupta U. et al. Breast-
feeding and childhood cancer. Indian Paediatrics 30:
652-7, 1993.
26. Davis MK, Savitz DA, Graubard BI. Infant feeding and
childhood cancer. Lancet 1: 365-8, 1988.
27. Richie JP. The role of glutathione in aging and cancer.
Exp Gerontol 27: 615-26, 1992.
28. Newberne PM, Butler WH. Acute and chronic effects of
aflatoxins B1 on the liver of domestic and laboratory
animals: A review. Cancer Res 29: 236-50, 1969.
29. Meerman JHN, Beland FA, Ketterer B, Srai SKF et al.
Identification of glutathione conjugates formed from N-hydroxy-2-
acetylaminofluorene in the rat. Chem Biol Interact 39:
149-68, 1982.
30. Boyland E, Sims P. The metabolism of benz(a)anthracene
and dibenz(a,h)anthracene and their 5,6-dihydro
derivatives by rat liver homogenates. Biochem J 97:
7-16, 1965.
31. Waterfall JF, Sims P. Epoxy derivatives of aromatic
polycyclic hydrocarbons. The properties and metabolism
of epoxides related to benzo(a)pyrene and to 7-8 and 9-
dihydrobenzo(a)pyrene. Biochem J 128: 265-77, 1972.
32. Yamazoe Y, Roth RW, Kadlubar FF. Reactivity of benzidine
diimine with DNA to form N-(deoxyguanosin-9-yl)-
benzidine. Carcinogenesis 7: 179-82, 1986.
33. Bounous G, Papenburg R, Kongshavn PAL, Gold P et al.
Dietary whey protein inhibits the development of dimethylhydrazine-
induced malignancy. Clin Invest Med 11: 213-7, 1988.
34. McIntosh GH, Regester GQ, Le Leu RK, Royle PJ. Dairy
proteins protect against dimethylhydrazine-induced
intestinal cancers in rats. J Nutr 125: 809-16, 1995.
35. Frei E, Bertram B, Wiessler M. Reduced glutathione
inhibits the alkylation by N-nitrosodimethylamine of
liver DNA in vivo and microsomal fraction in vitro. Chem
Biol Interact 55: 123-37, 1985.
36. Roberts JJ, Warwick GP. Mode of action of alkylating
agents in formation of S-ethyl cysteine from ethyl
methanesulphonate. Nature 179: 1181, 1958.
37. Coles B, Srai SKS, Waynforth B, Ketterer B. The major
role of glutathione in the excretion of N, N-dimethyl-4-
aminoazobenzene in the rat. Chem Biol Interact 47:
307-23, 1983.
38. Sims P. The metabolism of 3-methylcholanthrene and some
related compounds by rat liver homogenates. Biochem J
98: 215-28, 1966.
39. Sims P. The metabolism of 7- and 12-methylbenz(a)anthra-
cenes and their derivatives. Biochem J 105: 591-8, 1967.
40. Djuric Z, Coles B, Fifer EK, Ketterer B et al. In vivo
and in vitro formation of glutathione conjugates from
the K-region epoxides of 1-nitropyrene. Carcinogenesis
8: 1781-6, 1987.
41. Ripple MO, Henry W, Rago R, Wilding G. Prooxidant-
antioxidant shift induced by androgen treatment of
human prostate carcinoma cells. J Nat Cancer Inst 89:
40-8, 1997.
42. Hazelton GA, Lang CA. Glutathione contents of tissues in
the aging mouse. Biochem J 188: 25-30, 1980.
43. Lang CA, Richie JP, Chen TS. Differential glutathione
and cysteine levels in the brain of the aging mouse. Fed
Am Soc Exp Biol, 1988. [Abstract 8327]
44. Lang CA, Naryshkin S, Schneider DL, Mills BJ et al. Low
blood glutathione levels in healthy aging adults. J Lab
Clin Med 120: 720-5, 1992.
45. Jeandel C, Nicolas MB, Dubois F, Nabey-Belleville F et
al. Lipid peroxidation and free radical scavengers in
Alzheimer's disease. Gerontology
46: 275-82, 1989.
47. Calvin HI, Medvedovsky C, Worgul BV. Near-total
glutathione depletion and age-specific cataracts
induced by buthionine sulfoximine in mice. Science 28:
553-5, 1986.
48. Riederer P, Sofic E, Rausch WD, Schmidt B. Transition
metals, ferritin, glutathione and ascorbic acid in
Parkinsonian brains. J Neurochem 52: 515- 20, 1989.
49. Ebadi M, Srinivasan SK, Baxi MD. Oxidative stress and
antioxidant therapy in Parkinson's disease. Prog
Neurobiol 48: 1-19, 1996.
50. Kuzuya M, Naito M, Funaki C, Hayahi T et al. Protective
role of intracellular glutathione against oxidized low
density lipoprotein in cultured endothelial cells.
Biochem Biophys Res Commun 163: 1466-72, 1989.
51. Bounous G, Gervais F, Amer V, Batist G et al. The
influence of dietary whey protein on tissue
glutathione and the diseases of aging. Clin Invest Med
12: 343-9, 1989.
52. Blumberg JB, Meydani SN. Role of dietary antioxidants in
aging. In: Nutrition and Aging. Hutchinson MG, Munro HN
(Eds.). New York: Academic Press, 85-97, 1986.
53. Birt DF, Baker PY, Hruza DS. Nutritional evaluations of
three dietary levels of lactalbumin throughout the
lifespan of two generations of Syrian hamsters. J Nutr
112: 2151-60, 1982.
54. Birt DF, Schuldt GH, Salmasi S. Survival of hamsters fed
graded levels of two protein sources. Lab Anim Sci 32:
363-6, 1982.
55. Bray TM, Taylor CO. Enhancement of tissue glutathione
for antioxidant and immune functions in malnutrition.
Biochem Pharmacol 2113-23, 1994.
56. Puri RN, Meister A. Transport of glutathione, as g-
glutamylcylsteinylglycyl ester, into liver and kidney.
Proc Natl Acad Sci USA 80: 5258-60, 1983.
57. Anderson ME, Powric F, Puri RN, Meister A. Glutathione
monoethyl ester: Preparation, uptake by tissues, and
conversion to glutathione. Arch Biochem Biophys 239:
538-48, 1985.
58. Birnbaum SM, Winitz M, Greenstein JP. Quantitative
nutritional studies with water-soluble, chemically
defined diets. III. Individual amino acids as sources
of "non-essential" nitrogen. Arch Biochem Biophys 72:
428-36, 1957.
59. Bridgeman MME, Marsden M, MacNee W, Flenley DC et al.
Cysteine and glutathione concentrations in plasma and
bronchoalveolar lavage fluid after treatment with N-
acetylcysteine. Thorax 46: 39-42, 1991.
60. Williamson JM, Boettcher B, Meister A. Intracellular
cysteine delivery system that protects against toxicity
by promoting glutathione synthesis. Proc Natl Acad Sci
USA 79: 6246-9, 1982.
61. Mant TGK, Tempowski JH, Volans GN, Talbot JCC. Adverse
reactions to acetylcysteine and effects of overdose. Br
Med J 289: 217-19, 1984.
62. Koch SM, Leis AA, Stokic DS, Khawli FA et al. Side
effects of intravenous N-acetylcysteine. Am J Respir
Crit Care Med 149: A321, 1994.
63. Williamson JM, Meister A. Stimulation of hepatic
glutathione formation by administration of L-2-oxothiazolidine-4-
carboxylate, a 5-oxo-L, prolinase substrate. Proc Natl
Acad Sci USA 78: 936-9, 1981.
64. Baruchel S, Viau G, Olivier R, Bounous G. Nutriceutical
modulation of glutathione with a humanized native milk
serum protein isolate: Immunocal applications in AIDS
and cancer. In: Oxidative Stress and Redox Regulation:
Cellular Signaling, AIDS, Cancer and Other Diseases.
Symposium May 21- 24, 1996, Institut Pasteur. [In press]
65. Watanabe A, Higuchi K, Yasumura S, Shimizu Y et al.
Nutritional modulation of glutathione level and cellular
immunity in chronic hepatitis B and C. Hepatology 24:
1883, 1996.
 
K

kathy37

Guest
Boy, after reading this,I can only wonder how anybody lives
long enough to blow out the 100 candles on their birthday
cake without this product.

BTW, is there any particular reason one would consult with
the Chief Resident of a hospital emergency room on
nutritional issues? Last time I did it, it was only about a
fractured wrist.