Milk basic protein promotes bone formation is healthy young women according
to a new study. There are previous studies showing that whey protein has
some beneficial effect as well but milk basec protein - a fracture of whey
protein - is more efficient.
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Osteoporos Int. 2007 Mar;18(3):385-90. Epub 2006 Oct 18.
Milk basic protein increases bone mineral density and improves bone
metabolism in healthy young women.
Uenishi K, Ishida H, Toba Y, Aoe S, Itabashi A, Takada Y.
Laboratory of Physiological Nutrition, Kagawa Nutrition University, 3-9-21
Chiyoda, Sakado-shi, Saitama, 350-0288, Japan.
Effect of milk basic protein on bone metabolism in healthy young women.
INTRODUCTION: Milk has more beneficial effects on bone health than other
food sources. Recent in vitro and in vivo studies have shown that milk whey
protein, especially its basic protein fraction (milk basic protein, MBP),
contains several components capable of promoting bone formation and
inhibiting bone resorption. The object of this study was to examine the
effect of MBP on the bone mineral density and bone metabolism of healthy
young women. METHODS: Thirty-five healthy young women were randomly assigned
to treatment with either placebo or MBP (40 mg per day) for 6 months. The
bone mineral density (BMD) of the lumbar vertebrae L2-L4 of each subject was
measured by dual-energy X-ray absorptiometry (DXA) at 0 and 6 months of
treatment. Serum and urine indexes of bone metabolism were measured at 0, 3
and 6 months. All subjects completed the study in accordance with the
protocol. RESULTS: The mean rate of gain of lumbar BMD in the MBP group
(1.57%) was significantly higher than in the placebo group (0.13%, P=0.042).
When compared with the placebo group, urinary cross-linked N-telopeptides of
type-I collagen (NTx) were significantly decreased, and serum osteocalcin
was significantly increased in the MBP group at 6 months. CONCLUSION: These
results suggested that MBP supplementation was effective in increasing BMD
in young women and that this increase in BMD may be primarily mediated
through the promotion of bone formation and inhibition of bone resorption by
MBP supplementation. PMID: 17048062
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Juhana