Clin Genet. 1997 Sep;52(3):135-41. Related Articles, Links
A study of the cognitive and psychological profile in 16 children with
congenital or juvenile myotonic dystrophy.
Steyaert J, Umans S, Willekens D, Legius E, Pijkels E, de Die-Smulders C, Van
den Berghe H, Fryns JP.
Centre for Clinical Genetics, University of Maastricht, The Netherlands.
We report data on intelligence and on possibly associated psychopathology in 16
children and adolescents, between 7 and 18 years of age, with congenital or
juvenile myotonic dystrophy. We found that all the subjects have an
intelligence level below the population mean, four of them in the mentally
retarded range. An unexpected number of subjects are in the clinical range on
the Child Behavior Checklist. In nine of the 16 subjects, a child psychiatric
diagnosis was found using a standardized psychiatric interview. The most
frequent child psychiatric diagnosis was Attention Deficit Hyperactivity
Disorder.
PMID: 9377801 [PubMed - indexed for MEDLINE]
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J Nutr Biochem. 2004 Aug;15(8):467-72. Related Articles, Links
Dietary patterns and blood fatty acid composition in children with
attention-deficit hyperactivity disorder in Taiwan.
Chen JR, Hsu SF, Hsu CD, Hwang LH, Yang SC.
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei
110, Taiwan.
Nutritional factors may be relative to attention-deficit hyperactive disorder
(ADHD), although the pathogenic mechanism is still unknown. Based on the work
of others, we hypothesized that children with ADHD have altered dietary
patterns and fatty acid metabolism. Therefore, the aim of this study was to
evaluate dietary patterns and the blood fatty acid composition in children with
ADHD in the Taipei area of Taiwan. The present study found that 58 subjects
with ADHD (average age 8.5 years) had significantly higher intakes of iron and
vitamin C compared to those of 52 control subjects (average age 7.9 years) (P <
0.05). The blood total protein content in subjects with ADHD was significantly
lower than that in control subjects (P < 0.05). On the other hand, children
with ADHD had significantly higher blood iron levels compared to the control
children (P < 0.05). Additionally, plasma gamma-linolenic acid (18:3 n-6) in
children with ADHD was higher than that in control children (P < 0.05).
Concerning the composition of other fatty acids in the phospholipid isolated
from red blood cell (RBC) membranes, oleic acid (18:1n-9) was significantly
higher, whereas nervonic acid (24:1n-9), linoleic acid (18:2n-6), arachidonic
acid (20:4n-6), and docosahexaenoic acid (22:6n-3) were significantly lower in
subjects with ADHD (P < 0.05). Our results suggest that there were no
differences in dietary patterns of these children with ADHD except for the
intake of iron and vitamin C; however, the fatty acid composition of
phospholipid from RBC membranes in the ADHD children differed from that of the
normal children.
PMID: 15302081 [PubMed - in process]
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