Photosensitivity / iron



Photodermatol Photoimmunol Photomed. 2004 Feb; 20(1): 47-52. Links

Iron chelation can modulate UVA-induced lipid peroxidation and ferritin expression in human
reconstructed epidermis.

Seite S, Popovic E, Verdier MP, Roguet R, Portes P, Cohen C, Fourtanier A, Galey JB.

L'Oreal Recherche, Clichy, France L'Oreal Recherche, Aulnay-sous-bois, France.

BACKGROUND/PURPOSE: : As ferritin has been identified as an important factor in antioxidant defense
in cultured human skin cells, we evaluated UVA-induced lipid hydroperoxides (LPO) production and
ferritin expression in reconstructed human epidermis in vitro. RESULTS: : Ferritin is regularly
present in the basal layer of unirradiated epidermis both in the human skin in vivo and in the
reconstructed human epidermis in vitro. Following acute UVA exposure, ferritin expression increased
in basal epidermal cells in both models. Quantitative analysis showed that, in reconstructed human
epidermis, LPO and ferritin levels increased linearly with the UVA dose. An iron chelator, OR10141,
inhibited these inductions. CONCLUSION: : These findings demonstrate that reconstructed human
epidermis is a useful in vitro model to study UVA-induced oxidative stress and protection afforded
by iron chelators, antioxidants or UVA absorbers.

PMID: 14738533 [PubMed - in process]


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