Photosensitivity / iron

Discussion in 'Health and medical' started by Doe, Jan 24, 2004.

  1. Doe

    Doe Guest

    Photodermatol Photoimmunol Photomed. 2004 Feb; 20(1): 47-52. Links

    Iron chelation can modulate UVA-induced lipid peroxidation and ferritin expression in human
    reconstructed epidermis.

    Seite S, Popovic E, Verdier MP, Roguet R, Portes P, Cohen C, Fourtanier A, Galey JB.

    L'Oreal Recherche, Clichy, France L'Oreal Recherche, Aulnay-sous-bois, France.

    BACKGROUND/PURPOSE: : As ferritin has been identified as an important factor in antioxidant defense
    in cultured human skin cells, we evaluated UVA-induced lipid hydroperoxides (LPO) production and
    ferritin expression in reconstructed human epidermis in vitro. RESULTS: : Ferritin is regularly
    present in the basal layer of unirradiated epidermis both in the human skin in vivo and in the
    reconstructed human epidermis in vitro. Following acute UVA exposure, ferritin expression increased
    in basal epidermal cells in both models. Quantitative analysis showed that, in reconstructed human
    epidermis, LPO and ferritin levels increased linearly with the UVA dose. An iron chelator, OR10141,
    inhibited these inductions. CONCLUSION: : These findings demonstrate that reconstructed human
    epidermis is a useful in vitro model to study UVA-induced oxidative stress and protection afforded
    by iron chelators, antioxidants or UVA absorbers.

    PMID: 14738533 [PubMed - in process]

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