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Reduces common carotid intima-media thickness

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General fitness, health and nutrition
Published
27 May 2004
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4 June 2004
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Doe
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  1. Clin Nutr. 2004 Jun;23(3):423-433. Related Articles, Links

    Pomegranate juice consumption for 3 years by patients with
    carotid artery stenosis reduces common carotid intima-media
    thickness, blood pressure and LDL oxidation.

    Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman
    A, Dornfeld L, Volkova N, Presser D, Attias J, Liker
    H, Hayek T.

    The Lipid Research Laboratory, Rappaport Family Institute
    for Research in the Medical Sciences, Rambam Medical Center,
    Haifa 31096, Israel.

    Dietary supplementation with polyphenolic antioxidants to
    animals was shown to be associated with inhibition of LDL
    oxidation and macrophage foam cell formation, and
    attenuation of atherosclerosis development. We investigated
    the effects of pomegranate juice (PJ, which contains potent
    tannins and anthocyanins) consumption by atherosclerotic
    patients with carotid artery stenosis (CAS) on the
    progression of carotid lesions and changes in oxidative
    stress and blood pressure. Ten patients were supplemented
    with PJ for 1 year and five of them continued for up to 3
    years. Blood samples were collected before treatment and
    during PJ consumption. In the control group that did not
    consume PJ, common carotid intima-media thickness (IMT)
    increased by 9% during 1 year, whereas, PJ consumption
    resulted in a significant IMT reduction, by up to 30%, after
    1 year. The patients' serum paraoxonase 1 (PON 1) activity
    was increased by 83%, whereas serum LDL basal oxidative
    state and LDL susceptibility to copper ion-induced oxidation
    were both significantly reduced, by 90% and 59%,
    respectively, after 12 months of PJ consumption, compared to
    values obtained before PJ consumption. Furthermore, serum
    levels of antibodies against oxidized LDL were decreased by
    19%, and in parallel serum total antioxidant status (TAS)
    was increased by 130% after 1 year of PJ consumption.
    Systolic blood pressure was reduced after 1 year of PJ
    consumption by 21% and was not further reduced along 3 years
    of PJ consumption. For all studied parameters, the maximal
    effects were observed after 1 year of PJ consumption.
    Further consumption of PJ, for up to 3 years, had no
    additional beneficial effects on IMT and serum PON1
    activity, whereas serum lipid peroxidation was further
    reduced by up to 16% after 3 years of PJ consumption. The
    results of the present study thus suggest that PJ
    consumption by patients with CAS decreases carotid IMT and
    systolic blood pressure and these effects could be related
    to the potent antioxidant characteristics of PJ polyphenols.

    PMID: 15158307 [PubMed - as supplied by publisher]

    ------------------------------------------------------------
    --------------
    ------

    Who loves ya. Tom Jesus Was A Vegetarian!
    jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com Man Is A Herbivore!
    pages.ivillage.commanisaherbivore DEAD
    PEOPLE WALKING
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  2. I would suggest that the whole fruit be eaten, not just the
    juice, as many of the antiox goodies are lost and remain in
    the pulp along with fiber and other good stuff.

    Quoted message said:

    Clin Nutr. 2004 Jun;23(3):423-433. Related Articles, Links

    Pomegranate juice consumption for 3 years by patients with
    carotid artery stenosis reduces common carotid intima-media
    thickness, blood pressure and LDL oxidation.

    Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman
    A, Dornfeld L, Volkova N, Presser D, Attias J, Liker
    H, Hayek T.

    The Lipid Research Laboratory, Rappaport Family Institute
    for Research in the Medical Sciences, Rambam Medical
    Center, Haifa 31096, Israel.

    Dietary supplementation with polyphenolic antioxidants to
    animals was shown to be associated with inhibition of LDL
    oxidation and macrophage foam cell formation, and
    attenuation of atherosclerosis development. We investigated
    the effects of pomegranate juice (PJ, which contains potent
    tannins and anthocyanins) consumption by atherosclerotic
    patients with carotid artery stenosis (CAS) on the
    progression of carotid lesions and changes in oxidative
    stress and blood pressure. Ten patients were supplemented
    with PJ for 1 year and five of them continued for up to 3
    years. Blood samples were collected before treatment and
    during PJ consumption. In the control group that did not
    consume PJ, common carotid intima-media thickness (IMT)
    increased by 9% during 1 year, whereas, PJ consumption
    resulted in a significant IMT reduction, by up to 30%,
    after 1 year. The patients' serum paraoxonase 1 (PON 1)
    activity was increased by 83%, whereas serum LDL basal
    oxidative state and LDL susceptibility to copper ion-
    induced oxidation were both significantly reduced, by 90%
    and 59%, respectively, after 12 months of PJ consumption,
    compared to values obtained before PJ consumption.
    Furthermore, serum levels of antibodies against oxidized
    LDL were decreased by 19%, and in parallel serum total
    antioxidant status (TAS) was increased by 130% after 1 year
    of PJ consumption. Systolic blood pressure was reduced
    after 1 year of PJ consumption by 21% and was not further
    reduced along 3 years of PJ consumption. For all studied
    parameters, the maximal effects were observed after 1 year
    of PJ consumption. Further consumption of PJ, for up to 3
    years, had no additional beneficial effects on IMT and
    serum PON1 activity, whereas serum lipid peroxidation was
    further reduced by up to 16% after 3 years of PJ
    consumption. The results of the present study thus suggest
    that PJ consumption by patients with CAS decreases carotid
    IMT and systolic blood pressure and these effects could be
    related to the potent antioxidant characteristics of PJ
    polyphenols.

    PMID: 15158307 [PubMed - as supplied by publisher]

    -----------------------------------------------------------
    ---------------
    ------

    Who loves ya. Tom Jesus Was A Vegetarian!
    jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com Man Is A Herbivore!
    pages.ivillage.commanisaherbivore DEAD
    PEOPLE WALKING
    pages.ivillage.comdeadpeoplewalking

  3. Quoted message said:

    Subject: Re: Reduces common carotid intima-media thickness
    From: [email hidden]
    Date: 5/26/2004 12:26 PM Mountain Daylight Time
    Message-id: <[email hidden]>

    I would suggest that the whole fruit be eaten, not just the
    juice, as many of the antiox goodies are lost and remain in
    the pulp along with fiber and other good stuff.

    So based on this article you would recommend eating the
    equivalent of how many pomegranates ..?

    Based on this article you would NOW state .. "pomegranates
    reverse atherosclerosis .."

    What you should do maybe is to go into another line of work
    ..

    DO .. you .. work ..?

    You seem to spend alot of time out here ..

    Grunting and groaning and being no use at all ..

    How's that .. feel ..

    Who loves ya. Tom

    Quoted message said:


    Quoted message said:

    Clin Nutr. 2004 Jun;23(3):423-433. Related Articles, Links

    Pomegranate juice consumption for 3 years by patients with
    carotid artery stenosis reduces common carotid intima-
    media thickness, blood pressure and


    LDL

    Quoted message said:

    oxidation.

    Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A,
    Dornfeld L, Volkova


    N,

    Quoted message said:

    Presser D, Attias J, Liker H, Hayek T.

    The Lipid Research Laboratory, Rappaport Family Institute
    for Research in


    the

    Quoted message said:

    Medical Sciences, Rambam Medical Center, Haifa
    31096, Israel.

    Dietary supplementation with polyphenolic antioxidants to
    animals was shown


    to

    Quoted message said:

    be associated with inhibition of LDL oxidation and
    macrophage foam cell formation, and attenuation of
    atherosclerosis development. We investigated


    the

    Quoted message said:

    effects of pomegranate juice (PJ, which contains potent
    tannins and anthocyanins) consumption by atherosclerotic
    patients with carotid artery stenosis (CAS) on the
    progression of carotid lesions and changes in


    oxidative

    Quoted message said:

    stress and blood pressure. Ten patients were supplemented
    with PJ for 1 year and five of them continued for up to 3
    years. Blood samples were collected before treatment and
    during PJ consumption. In the control group that did


    not

    Quoted message said:

    consume PJ, common carotid intima-media thickness (IMT)
    increased by 9%


    during

    Quoted message said:

    1 year, whereas, PJ consumption resulted in a significant
    IMT reduction, by


    up

    Quoted message said:

    to 30%, after 1 year. The patients' serum paraoxonase 1
    (PON 1) activity was increased by 83%, whereas serum LDL
    basal oxidative state and LDL susceptibility to copper ion-
    induced oxidation were both significantly


    reduced,

    Quoted message said:

    by 90% and 59%, respectively, after 12 months of PJ
    consumption, compared to values obtained before PJ
    consumption. Furthermore, serum levels of


    antibodies

    Quoted message said:

    against oxidized LDL were decreased by 19%, and in
    parallel serum total antioxidant status (TAS) was
    increased by 130% after 1 year of PJ


    consumption.

    Quoted message said:

    Systolic blood pressure was reduced after 1 year of PJ
    consumption by 21%


    and

    Quoted message said:

    was not further reduced along 3 years of PJ consumption.
    For all studied parameters, the maximal effects were
    observed after 1 year of PJ


    consumption.

    Quoted message said:

    Further consumption of PJ, for up to 3 years, had no
    additional beneficial effects on IMT and serum PON1
    activity, whereas serum lipid peroxidation was further
    reduced by up to 16% after 3 years of PJ consumption. The
    results of the present study thus suggest that PJ
    consumption by patients with CAS decreases carotid IMT and
    systolic blood pressure and these effects could be related
    to the potent antioxidant characteristics of PJ
    polyphenols.

    PMID: 15158307 [PubMed - as supplied by publisher]

    ----------------------------------------------------------
    ----------------
    ------

    Who loves ya. Tom

    Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com
    Man Is A Herbivore!
    pages.ivillage.commanisaherbivore DEAD
    PEOPLE WALKING
    pages.ivillage.comdeadpeoplewalking

  4. "So based on this article you would recommend eating the
    equivalent of how many pomegranates ..?"

    It didn't give amounts of anything, so one can't answer your
    question, but we are glad to answer when possible, an open
    mind is a mind ready to strech and learn and to adjust once
    ernestly held beliefs in the face of new info and insight
    from others; glad to help.

  5. Quoted message said:

    Subject: Re: Reduces common carotid intima-media thickness
    From: [email hidden]
    Date: 5/26/2004 5:19 PM Mountain Daylight Time
    Message-id: <[email hidden]>

    "So based on this article you would recommend eating the
    equivalent of how many pomegranates ..?"

    It didn't give amounts of anything, so one can't answer
    your question,

    One could .. IF .. one KNEW how many pomegranates it takes
    to make a glass of juice .. eh ..

    Quoted message said:

    but we are glad to answer when possible,

    We .. ?

    You got a team ..?

    So when I kick your ass .. I kick the collective asses of
    your team .. ?

    May I suggest you get a better .. team ..

    My team seems to be constantly kicking your ass ..

    Or .. collective asses ..

    Quoted message said:

    an open mind is a mind ready to strech and learn and to
    adjust once ernestly held beliefs in the face of new info
    and insight from others; glad to help.

    No .. I believe you didn't actually ADD a .. fkg .. thing ..

    Just more sht from your head ..

    Which .. I may add .. didn't decrease the AMOUNT of sht IN
    your head by any appreciable amount ..

    So you can STILL .. be .. called .. a .. shthd ..

    Who loves ya. Tom

    Who loves ya. Tom Jesus Was A Vegetarian!
    jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com Man Is A Herbivore!
    pages.ivillage.commanisaherbivore DEAD
    PEOPLE WALKING
    pages.ivillage.comdeadpeoplewalking

  6. They didn't say how much juice was used, cup or not. For
    all we know, the juice of one fruit was used, and eating
    it would have gained all it's nutrition that the juice
    is missing.

  7. Quoted message said:
    Quoted message said:

    Mark De Toad days: "So based on this article you would
    recommend eating the equivalent of


    how

    Quoted message said:
    Quoted message said:

    many pomegranates ..?"

    It didn't give amounts of anything, so one can't answer
    your question,


    Quoted message said:

    Doe comments: One could .. IF .. one KNEW how many
    pomegranates it takes to make a glass


    of

    Quoted message said:

    juice .. eh ..

    Buy several of them and then juice them and measure the
    results. Off hand, I suspect one might do it, depending on
    the glass size. Six ounces perhaps?? Ellagic acid is good
    search word for pomegranates. They are an ancient food.

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