Clin Nutr. 2004 Jun;23(3):423-433. Related Articles, Links
Pomegranate juice consumption for 3 years by patients with
carotid artery stenosis reduces common carotid intima-media
thickness, blood pressure and LDL oxidation.
Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman
A, Dornfeld L, Volkova N, Presser D, Attias J, Liker
H, Hayek T.
The Lipid Research Laboratory, Rappaport Family Institute
for Research in the Medical Sciences, Rambam Medical Center,
Haifa 31096, Israel.
Dietary supplementation with polyphenolic antioxidants to
animals was shown to be associated with inhibition of LDL
oxidation and macrophage foam cell formation, and
attenuation of atherosclerosis development. We investigated
the effects of pomegranate juice (PJ, which contains potent
tannins and anthocyanins) consumption by atherosclerotic
patients with carotid artery stenosis (CAS) on the
progression of carotid lesions and changes in oxidative
stress and blood pressure. Ten patients were supplemented
with PJ for 1 year and five of them continued for up to 3
years. Blood samples were collected before treatment and
during PJ consumption. In the control group that did not
consume PJ, common carotid intima-media thickness (IMT)
increased by 9% during 1 year, whereas, PJ consumption
resulted in a significant IMT reduction, by up to 30%, after
1 year. The patients' serum paraoxonase 1 (PON 1) activity
was increased by 83%, whereas serum LDL basal oxidative
state and LDL susceptibility to copper ion-induced oxidation
were both significantly reduced, by 90% and 59%,
respectively, after 12 months of PJ consumption, compared to
values obtained before PJ consumption. Furthermore, serum
levels of antibodies against oxidized LDL were decreased by
19%, and in parallel serum total antioxidant status (TAS)
was increased by 130% after 1 year of PJ consumption.
Systolic blood pressure was reduced after 1 year of PJ
consumption by 21% and was not further reduced along 3 years
of PJ consumption. For all studied parameters, the maximal
effects were observed after 1 year of PJ consumption.
Further consumption of PJ, for up to 3 years, had no
additional beneficial effects on IMT and serum PON1
activity, whereas serum lipid peroxidation was further
reduced by up to 16% after 3 years of PJ consumption. The
results of the present study thus suggest that PJ
consumption by patients with CAS decreases carotid IMT and
systolic blood pressure and these effects could be related
to the potent antioxidant characteristics of PJ polyphenols.
PMID: 15158307 [PubMed - as supplied by publisher]
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