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    Clin Chim Acta. 2004 Mar;341(1-2):165-72. Related Articles, Links

    Blood lactoferrin release induced by running exercise in normal volunteers: antibacterial activity.

    Inoue H, Sakai M, Kaida Y, Kaibara K.

    Radioisotopes Institute for Basic and Clinical Medicine, Kurume University School of Medicine, 67
    Asahi-machi, Kurume 830-0011, Japan.

    Background: The aim of this study was to determine serum lactoferrin concentrations and serum
    antibacterial activity before and after running exercise. Methods: Twenty-four healthy young men
    were randomly assigned to high, middle, or low intensity of exercise groups (5000 steps running at
    180, 130, and 80 steps/min, respectively). Blood samples were collected at baseline and immediately,
    1 and 4 h after exercise. Concentrations of circulating neutrophils, serum lactoferrin, iron in
    whole blood, and serum iron were measured. Antibacterial activity of serum was evaluated using live
    Micrococcus luteus. Results: The numbers of circulating neutrophils were increased by 20.0% and
    15.5% 1 h after exercise in high and middle groups (both P<0.01), respectively. Serum lactoferrin
    concentrations were significantly increased immediately after exercise by 48.3% and 33.0% in the
    high and middle groups (both P<0.01), respectively. No significant changes in total iron or serum
    iron concentrations were observed during the study. Antibacterial activities of serum collected
    immediately after exercise in the high and middle groups were significantly stronger than those
    before exercise, by 31.2% and 25.4% (both P<0.05), respectively. Conclusions: Serum lactoferrin
    concentrations are increased immediately after running exercise and may play an antibacterial role
    in host defenses before mobilization of neutrophils into the circulating pool.

    PMID: 14967173 [PubMed - in process]


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