two cholesterol questions

Mon, 17 May 2004 22:36:59 GMT in article

Quoted message said:

OK. Among the popular ones do you know which is which or do
you have a reference. Thanks.

According to some articles the more lipid-soluble the
statin, the greater propensity it has to cross the blood-
brain barrier and affect the central nervous system.
According to some reports simvastatin is the most lipophilic
drug in its class; pravastatin is the least lipophilic. Some
reports state that atorvastatin does not cross the blood-
brain barrier, whereas others state that the drug has
intermediate lipophilicity.

My educated guess is that at least lovastatin, mevastatin,
and simvastatin can cross the b-b-b and at least pravastatin
cannot, but I could be wrong.

References

Sparks DL, Connor DJ, Browne PJ, Lopez JE, Sabbagh MN. HMG-
CoA reductase inhibitors (statins) in the treatment of
Alzheimer's disease and why it would be ill-advise to use
one that crosses the blood-brain barrier. J Nutr Health
Aging. 2002;6(5):324-31. PMID: 12474023 [PubMed - in
process] <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi-
?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12474023>

Serajuddin AT, Ranadive SA, Mahoney EM. Relative
lipophilicities, solubilities, and structure-pharmacological
considerations of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-
CoA) reductase inhibitors pravastatin, lovastatin,
mevastatin, and simvastatin. J Pharm Sci. 1991 Sep;80(9):830-
4. PMID: 1800703 [PubMed - indexed for MEDLINE] <URL:http:/-
/www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pub-
med&dopt=Abstract&list_uids=1800703>

--
Matti Narkia

On Thu, 20 May 2004 09:13:41 -0400, Mosaic M_uns <[email hidden]>

Quoted message said:

Meet Bob Pastorio.

I know Bob. Lovely guy. Great cook.

(Who are you?)

In article <[email hidden]>,

Quoted message said:

Meet Bob Pastorio.

Bob likes to think he is an upscale, right on kind of guy.
But in the darkness, he would prefer to endanger the lives
of cardiac care patients so he TROLLS sci.med.cardiology
dozens of times each day. Bob

[snipped all newsgroups except the one I read and the one
mentioned above]

I have a philosophy that once you catch a person at one lie,
the rest of what they say comes into question. The above
claims that Bob trolls sci.med.cardiology dozens of times
each day. So I went to that group and did a search for an
author of "this one". I came up with 26 posts. I don't know
exactly how many days that covers, but one post I picked at
random was dated May 12. This means four a day, not dozens.
I did this same test a couple of weeks ago when I saw this
exact same post. Bob had 11 posts then, presumably spanning
roughly the same time span.

I don't know what Bob posts to sci.med.cardiology, because
despite controlled high cholesterol and high blood pressure,
my cardiovascular system is in decent shape, and I know next
to nothing about cardiology. Bob is a welcome poster in
rec.food.cooking, where I post and follow many threads.

--
Dan Abel Sonoma State University AIS [email hidden]

Davida Chazan - The Chocolate Lady said:

On Thu, 20 May 2004 09:13:41 -0400, Mosaic M_uns

Quoted message said:

Meet Bob Pastorio.

I know Bob. Lovely guy. Great cook.

(Who are you?)

(Not Mu)

If you truly know and love Bob, you would try to help him
with his obsessions.

At the very least, you should pray that God cures him before
these obsessions become the only things in his life.

He certainly remains in my prayers to God, in Christ's name.

May he accept Christ as his personal Lord and Savior,
someday, so that He will cure his afflictions.

Servant to the humblest person in the universe,

Andrew

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
heartmdphd.comheartmdphd.comOpen ↗

**
Who is the humblest person in the universe?
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What is all this about?
makeashorterlink.commakeashorterlink.comOpen ↗

Is this spam?
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Dan Abel said:

In article <[email hidden]>,

Quoted message said:

Meet Bob Pastorio.

Bob likes to think he is an upscale, right on kind of
guy. But in the darkness, he would prefer to endanger
the lives of cardiac care patients so he TROLLS
sci.med.cardiology dozens of times each day. Bob

[snipped all newsgroups except the one I read and the one
mentioned above]

I have a philosophy that once you catch a person at one
lie, the rest of what they say comes into question. The
above claims that Bob trolls sci.med.cardiology dozens of
times each day.

Folks who subscribe to SMC probably can recall at least one
instance where Bob has posted a dozen or more messages in
any one given day.

Servant to the humblest person in the universe,

Andrew

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
heartmdphd.comheartmdphd.comOpen ↗

**
Who is the humblest person in the universe?
makeashorterlink.commakeashorterlink.comOpen ↗

What is all this about?
makeashorterlink.commakeashorterlink.comOpen ↗

Is this spam?
makeashorterlink.commakeashorterlink.comOpen ↗

in article [email hidden], Dr. Andrew B.
Chung, MD/PhD at [email hidden] wrote on 20/5/04 12:17 pm:

Quoted message said:

Davida Chazan - The Chocolate Lady said:

Mosaic M_uns said:

Meet Bob Pastorio.

I know Bob. Lovely guy. Great cook.

(Who are you?)

(Not Mu)

If you truly know and love Bob, you would try to help him
with his obsessions.

You know, some of us here don't care much about your views
of God, let alone Christ. There are places to discuss this
sort of thing, but this is not it. Please, take your
obsessions about Bob, diet and all other things and go
somewhere else more appropriate. Ellen >

Quoted message said:

At the very least, you should pray that God cures
him before these obsessions become the only things
in his life.

He certainly remains in my prayers to God, in
Christ's name.

May he accept Christ as his personal Lord and Savior,
someday, so that He will cure his afflictions.

Servant to the humblest person in the universe,

Andrew

--
Dr. Andrew B. Chung, MD/PhD Board-Certified Cardiologist
heartmdphd.comheartmdphd.comOpen ↗

** Who is the humblest person in the universe?
makeashorterlink.commakeashorterlink.comOpen ↗

What is all this about?
makeashorterlink.commakeashorterlink.comOpen ↗

Is this spam? makeashorterlink.commakeashorterlink.comOpen ↗

In article said:

Dan Abel wrote:

Quoted message said:

Quoted message said:

I have a philosophy that once you catch a person at one
lie, the rest of what they say comes into question. The
above claims that Bob trolls sci.med.cardiology dozens
of times each day.

Folks who subscribe to SMC probably can recall at least
one instance where Bob has posted a dozen or more messages
in any one given day.

There's a whole lot of difference between "dozens of
times each day" and "a dozen or more messages in any one
given day".

--
Dan Abel Sonoma State University AIS [email hidden]

Dr. Andrew B. Chung said:

Dan Abel said:

In article <[email hidden]>,

Quoted message said:

Meet Bob Pastorio.

Bob likes to think he is an upscale, right on kind of
guy. But in the darkness, he would prefer to endanger the
lives of cardiac care patients so he TROLLS
sci.med.cardiology dozens of times each day. Bob

[snipped all newsgroups except the one I read and the one
mentioned above]

I have a philosophy that once you catch a person at one
lie, the rest of what they say comes into question.

Well, meet Dr. Andrew B. Chung who lies on a daily basis -
just recently he claimed to have admitting privileges at
three hospitals which unanimously said, no, he didn't. And
his apologist, Mu of the many names, and who is also a liar.

I especially like that "in the darkness" thing from
anonymous Mu. He and Chung share the same darkness of
the soul...

Quoted message said:

The above claims that Bob trolls

Quoted message said:

sci.med.cardiology dozens of times each day.

Folks who subscribe to SMC probably can recall at least
one instance where Bob has posted a dozen or more
messages in any one given day.

Chung logic and "truth" at its finest.
Note: *One* day with 12 or more posts = dozens of
times each day.
Note: A dozen or more posts in one day = all TROLLS.

Trolling has a relatively specific meaning to everyone
but Chung and
Mu. To them, it's whatever they don't like.

If you want to see a spectacularly hilarious troll, check in
with SMC on any given day when Chung posts his FAQ that he
says was created by others who wish to remain anonymous.
<LOL> Except the writing style is pure Chung; sloppy
grammar, illogic, self-serving egotism, and duplicity waving
around in the light of day.

It would be zany except he's a doctor with life and
death responsibility and, even more important, authority
for others.

Bob

Dan Abel said:

In article <[email hidden]>,

Quoted message said:

Dan Abel wrote:

Quoted message said:

Quoted message said:

I have a philosophy that once you catch a person at
one lie, the rest of what they say comes into
question. The above claims that Bob trolls
sci.med.cardiology dozens of times each day.

Folks who subscribe to SMC probably can recall at least
one instance where Bob has posted a dozen or more
messages in any one given day.

There's a whole lot of difference between "dozens of
times each day" and "a dozen or more messages in any one
given day".

There is a lot more difference between "dozens of times
*every* day" and "a dozen or more messages in any one
given day."

Servant to the humblest person in the universe,

Andrew

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
heartmdphd.comheartmdphd.comOpen ↗

**
Who is the humblest person in the universe?
makeashorterlink.commakeashorterlink.comOpen ↗

What is all this about?
makeashorterlink.commakeashorterlink.comOpen ↗

Is this spam?
makeashorterlink.commakeashorterlink.comOpen ↗

Dr. Andrew B. Chung said:

Dan Abel said:

In article <[email hidden]>,

Quoted message said:

Dan Abel wrote:

Quoted message said:

>I have a philosophy that once you catch a person at one
>lie, the rest of what they say comes into question. The
>above claims that Bob trolls sci.med.cardiology dozens
>of times each day.

Folks who subscribe to SMC probably can recall at least
one instance where Bob has posted a dozen or more
messages in any one given day.

There's a whole lot of difference between "dozens of
times each day" and "a dozen or more messages in any one
given day".

There is a lot more difference between "dozens of times
*every* day" and "a dozen or more messages in any one
given day."

<LOL> Well, of course there is. Chung cancels the intended
effect his prior message because of his crippled
understanding of English. Too funny... In the real world,
"every day" = "each day" and "each day" most assuredly does
not = "any one given day"

But Mu said:

Bob likes to think he is an upscale, right on kind of
guy. But in the darkness, he would prefer to endanger the
lives of cardiac care patients so he TROLLS
sci.med.cardiology dozens of times each day.

And it was that silly assertion that was being so tidily
refuted. Poor Chung clinging to his non sequitur as though
it proved what he'd like it to mean. <LOL> Mu just lied
again and Chung tried to swear to it, but even he couldn't
handle that much of a lie... and he apparently grasped the
edges of the illogic of it. Never thought I'd see the day...

Bob