Accumulation of iron in rheumatoid arthritis synovium

I'm glad you posted this, it confirms one example that is a
weakness with most of the iron abstracts. In this cas
inflamation promotes iron uptake and iron was not the cause
of the underlying disorder. In this example iron is an
effect not a cause. This question needs to be asked about
all studies where one is found in association with another
thing. Thanks.

Quoted message said:

Med Sci Monit. 2004 Mar 23;10(4):BR91-BR95. [Epub ahead of
print] Related Articles, Links

Proinflammatory cytokines increase iron uptake into human
monocytes and synovial fibroblasts from patients with
rheumatoid arthritis.

Telfer JF, Brock JH.

Department of Immunology, Western Infirmary, University of
Glasgow, United Kingdom.

Background: It has been hypothesized that iron is stored in
the synovium of patients with rheumatoid arthritis which
perpetuates inflammation by aiding the production of oxygen
free radicals. Proinflammatory cytokines are produced by
macrophages and lymphocytes present within synovium and by
mononuclear cells of in synovial fluid from patients with
rheumatoid arthritis. There are two known systems for iron
uptake. The first involves binding of iron to transferrin
and uptake via transferrin receptors. The second involves
uptake by low molecular weight organic anions such as
ascorbate and citrate (non-transferrin bound uptake).
Material/Methods: Proinflammatory cytokines (IL-1, Il-6,
TNF? and interferon ?) were added to fibroblasts isolated
from patients with rheumatoid arthritis and human monocytes
in culture and their effect on 59Fe-transferrin and citrate
uptake was determined. Results: Proinflammatory cytokines
increase transferrin and non-transferrin bound iron uptake
into human monocytes and increase transferrin-bound iron
uptake by synovial fibroblasts, but have no effect on non-
transferrin bound uptake into fibroblasts. Conclusions:
Proinflammatory cytokines produced in human rheumatoid
arthritis synovium and synovial fluid may contribute to the
accumulation of iron that occurs in rheumatoid arthritis
synovium which may lead to damage to synovial fibroblasts,
macrophages and lymphocytes.

PMID: 15039637 [PubMed - as supplied by publisher]

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------

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<[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

I'm glad you posted this, it confirms one example that is
a weakness with most of the iron abstracts. In this case
inflamation promotes iron uptake and iron was not the
cause of the underlying disorder. In this example iron is
an effect not a cause. This question needs to be asked
about all studies where one is found in association with
another thing. Thanks.

I wonder if we're doing the right thing by pointing out the
error of his ways to him. Maybe we'd be better off having a
word with God, and asking him to put him right, as he thinks
he's on a divine mission anyway.

Quoted message said:

Subject: Re: Accumulation of iron in rheumatoid arthritis synovium
From: [email hidden]
Date: 3/25/2004 11:43 AM Mountain Standard Time
Message-id: <[email hidden]>

I'm glad you posted this, it confirms one example that is a
weakness with most of the iron abstracts. In this cas
inflamation promotes iron uptake and iron was not the cause
of the underlying disorder.

<<anip>> may contribute to the accumulation of iron <<anip>>

MAY .. contribute ..

You KNOW what .. contribute .. MEANS .. ?

It means .. ADDITIVE .. jrkff ..

Quoted message said:

In this example iron is an effect not a cause. This
question needs to be asked about all studies where one is
found in association with another thing. Thanks.

Non-transferrin bound iron .. free iron .. iron not
bound up ..

EXCESS .. iron ..

Understand .. ?

Quoted message said:

Quoted message said:

Med Sci Monit. 2004 Mar 23;10(4):BR91-BR95. [Epub ahead of
print] Related Articles, Links

Proinflammatory cytokines increase iron uptake into human
monocytes and synovial fibroblasts from patients with
rheumatoid arthritis.

Telfer JF, Brock JH.

Department of Immunology, Western Infirmary, University of
Glasgow, United Kingdom.

Background: It has been hypothesized that iron is stored
in the synovium of patients with rheumatoid arthritis
which perpetuates inflammation by aiding

the

Quoted message said:

production of oxygen free radicals. Proinflammatory
cytokines are produced

by

Quoted message said:

macrophages and lymphocytes present within synovium and by
mononuclear cells

of

Quoted message said:

in synovial fluid from patients with rheumatoid arthritis.
There are two

known

Quoted message said:

systems for iron uptake. The first involves binding of
iron to transferrin

and

Quoted message said:

uptake via transferrin receptors. The second involves
uptake by low

molecular

Quoted message said:

weight organic anions such as ascorbate and citrate (non-
transferrin bound uptake). Material/Methods:
Proinflammatory cytokines (IL-1, Il-6, TNF? and interferon
?) were added to fibroblasts isolated from patients with

rheumatoid

Quoted message said:

arthritis and human monocytes in culture and their
effect on

59Fe-transferrin

Quoted message said:

and citrate uptake was determined. Results:
Proinflammatory cytokines

increase

Quoted message said:

transferrin and non-transferrin bound iron uptake into
human monocytes and increase transferrin-bound iron uptake
by synovial fibroblasts, but have no effect on non-
transferrin bound uptake into fibroblasts. Conclusions:
Proinflammatory cytokines produced in human rheumatoid
arthritis synovium

and

Quoted message said:

synovial fluid may contribute to the accumulation of iron
that occurs in rheumatoid arthritis synovium which may
lead to damage to synovial

fibroblasts,

Quoted message said:

macrophages and lymphocytes.

PMID: 15039637 [PubMed - as supplied by publisher]

----------------------------------------------------------
----------------
------

Who loves ya. Tom

Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗
Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD
PEOPLE WALKING
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Quoted message said:

Subject: Re: Accumulation of iron in rheumatoid arthritis synovium

Med Sci Monit. 2004 Mar 23;10(4):BR91-BR95. [Epub ahead of
print] Related

Quoted message said:

Articles, Links

Proinflammatory cytokines increase iron uptake into human
monocytes and synovial fibroblasts from patients with
rheumatoid arthritis.

Telfer JF, Brock JH.

Department of Immunology, Western Infirmary, University of
Glasgow, United Kingdom.

Background: It has been hypothesized that iron is stored in
the synovium of patients with rheumatoid arthritis which
perpetuates inflammation by aiding

the

Quoted message said:

production of oxygen free radicals. Proinflammatory
cytokines are produced by macrophages and lymphocytes
present within synovium and by mononuclear cells

of

Quoted message said:

in synovial fluid from patients with rheumatoid arthritis.
There are two known systems for iron uptake. The first
involves binding of iron to transferrin and uptake via
transferrin receptors. The second involves uptake by low
molecular weight organic anions such as ascorbate and
citrate (non-transferrin bound uptake). Material/Methods:
Proinflammatory cytokines (IL-1, Il-6, TNF? and interferon
?) were added to fibroblasts isolated from patients with
rheumatoid arthritis and human monocytes in culture and
their effect on 59Fe-transferrin and citrate uptake was
determined. Results: Proinflammatory cytokines increase
transferrin and non-transferrin bound iron uptake into
human monocytes and increase transferrin-bound iron uptake
by synovial fibroblasts, but have no effect on non-
transferrin bound uptake into fibroblasts. Conclusions:
Proinflammatory cytokines produced in human rheumatoid
arthritis synovium and synovial fluid may contribute to the
accumulation of iron that occurs in rheumatoid arthritis
synovium which may lead to damage to synovial

fibroblasts,

Quoted message said:

macrophages and lymphocytes.

PMID: 15039637 [PubMed - as supplied by publisher]

-----------------------------------------------------------
---------------
------

Who loves ya. Tom

Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗
Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

This abstract is a good example where iron is a result of an
underlying condition that causes increased stores of it. It
is an important example because it shows that we must divide
out what is cause from what is effect where two things
appear togather. Thanks for the example.

"contribute and additive"

Yes a very important point, iron is being contributed to
current stores by addition, and it is happening because of
something else; iron is not causing the disease but the
disease causes the amount of iron.

Quoted message said:

Subject: Re: Accumulation of iron in rheumatoid arthritis synovium
From: [email hidden]
Date: 3/25/2004 7:50 PM Mountain Standard Time
Message-id: <[email hidden]>

"contribute and additive"

Yes a very important point, iron is being contributed to
current stores by addition, and it is happening because of
something else; iron is not causing the disease but the
disease causes the amount of iron.

And you are .. guessing .. the above .. ?

Iron .. from inside the body is ADDING TO .. the iron
already present in the joints ..

Iron KNOWN to be there ..

KNOWN to be .. there ..

YOU .. say .. iron isn't the .. cause ..

I say it is ..

Many studies SHOW clearly iron causes destruction of joints
..

YOU .. show me where it .. doesn't ..

A cite or two will suffice ..

Thanks ..

Med Sci Monit. 2004 Mar 23;10(4):BR91-BR95. [Epub ahead of
print] Related Articles, Links

Proinflammatory cytokines increase iron uptake into human
monocytes and synovial fibroblasts from patients with
rheumatoid arthritis.

Telfer JF, Brock JH.

Department of Immunology, Western Infirmary, University of
Glasgow, United Kingdom.

Background: It has been hypothesized that iron is stored in
the synovium of patients with rheumatoid arthritis which
perpetuates inflammation by aiding the production of oxygen
free radicals. Proinflammatory cytokines are produced by
macrophages and lymphocytes present within synovium and by
mononuclear cells of in synovial fluid from patients with
rheumatoid arthritis. There are two known systems for iron
uptake. The first involves binding of iron to transferrin
and uptake via transferrin receptors. The second involves
uptake by low molecular weight organic anions such as
ascorbate and citrate (non-transferrin bound uptake).
Material/Methods: Proinflammatory cytokines (IL-1, Il-6,
TNF? and interferon ?) were added to fibroblasts isolated
from patients with rheumatoid arthritis and human monocytes
in culture and their effect on 59Fe-transferrin and citrate
uptake was determined. Results: Proinflammatory cytokines
increase transferrin and non-transferrin bound iron uptake
into human monocytes and increase transferrin-bound iron
uptake by synovial fibroblasts, but have no effect on non-
transferrin bound uptake into fibroblasts. Conclusions:
Proinflammatory cytokines produced in human rheumatoid
arthritis synovium and synovial fluid may contribute to the
accumulation of iron that occurs in rheumatoid arthritis
synovium which may lead to damage to synovial fibroblasts,
macrophages and lymphocytes.

PMID: 15039637 [PubMed - as supplied by publisher]

------------------------------------------------------------
--------------
------

Who loves ya. Tom Jesus Was A Vegetarian!
jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

"doe" <[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

Quoted message said:

Subject: Re: Accumulation of iron in rheumatoid arthritis
synovium From: [email hidden] Date: 3/25/2004 11:43
AM Mountain Standard Time Message-id: <[email hidden]-
net.com>

I'm glad you posted this, it confirms one example that is
a weakness with most of the iron abstracts. In this cas
inflamation promotes iron uptake and iron was not the
cause of the underlying disorder.

<<anip>> may contribute to the accumulation of iron
<<anip>>

MAY .. contribute ..

You KNOW what .. contribute .. MEANS .. ?

It means .. ADDITIVE .. jrkff ..

No it doesn't.

"Contribute" is a verb "Additive" is a noun.

They are different.

The term "Cytoadhsion" springs to mind :o)

On 26 Mar 2004 03:18:32 GMT, [email hidden] (doe) posted:

Hence the expression "Tommy Rot" The symptoms are spots on
the screen.................

"Moosh🙂" <[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

On 26 Mar 2004 03:18:32 GMT, [email hidden]
(doe) posted:

Hence the expression "Tommy Rot" The symptoms are spots on
the screen.................

LOL !!!

I like that one :o)

On 27 Mar 2004 19:51:41 GMT, [email hidden] (doe) posted:

Quoted message said:

Quoted message said:

Subject: Re: Accumulation of iron in rheumatoid arthritis
synovium From: "Moosh🙂" [email hidden] Date: 3/26/2004
11:42 PM Mountain Standard Time Message-id:
<[email hidden]>

On 26 Mar 2004 03:18:32 GMT, [email hidden]
(doe) posted:

Hence the expression "Tommy Rot" The symptoms are spots on
the screen.................

Moosh .. I see you have contributed quite a bit since you
have been around .. eh ..

How's that .. feel ..

Heh .. heh ..

I've still got spots before my eyes, Tommy. Must go the the
bloodbank again and use my fifth pseudonym.

Or perhaps you could adjust the bounce rate on your
period key?