S
Soft-Eng
Guest
Orac <[email protected]> wrote in message news:<[email protected]>...
> In article <[email protected]>, [email protected] (soft-
> eng) wrote:
>
> > Orac <[email protected]> wrote in message news:<orac-
> > [email protected]>...
> > > In article <[email protected]>, [email protected] (soft-
> > > eng) wrote:
> > >
> > > > "Rich Shewmaker" <[email protected]> wrote in message news:<h-KdnQ6LdPlBwpTdRVn-
> > > > [email protected]>...
> > > >
> > > > > It is interesting that you selected digitalis as your example. This drug is quite toxic in
> > > > > overdose, and the toxic dose is only slightly greater than
> > > >
> > > > Did you know an overdose of salt will kill you?
> > >
> > > But it would take a hell of a lot to do so in a person with normal kidney function.
> > >
> > >
> > > > Or that a little bit less than a fatal overdose would damage your brain? Or that overdoing
> > > > it even in normal usage would increase your blood pressure? And yet, if salt weren't
> > > > available at all, you would have many health problems from salt deprivation?
> > >
> > > The vast majority of people get more than adequate salt in their daily diet. Even vegans.
> > > Supplementation is rarely necessary or helpful.
> > >
> > >
> > > > Many everyday ingestibles are toxic in overdose.
> > >
> > > Straw man. The difference is that, in contrast to your other example, digitalis has a rather
> > > narrow range of efficacy. The range between an ineffective dose and a toxic dose is narrow and
> > > easily crossed. Moreover, its pharmacokinetics are such that it takes a long time to build up
> > > a therapeutic dose and a long time for it to be metabolized away when the toxic dose has been
> > > passed. Worse, there is a fair amount of person-to-person variation in its metabolism.
> > >
> > >
> > > > But Foxglove was actually IN USE by herbal dispensers before medicine in its modern form
> > > > acquired it.
> > > >
> > > > I am not saying standardization is not of benefit. Obviously it is. But that doesn't relate
> > > > to any arguments of substance in this thread.
> > >
> > > Yes it does. The whole point is that using digitalis in a pure, standardized form is
> > > inherently safer and more efficacious than relying on hit-and-miss dosing through the
> > > administration of foxglove leaves.
> >
> > Nobody said analysis and standardization is not of benefit. That's just a strawman you inserted
> > in the debate.
>
> Wrong. Your example of salt as an example of how "everyday substances are toxic in overdose" was
> the obvious strawman. I was merely responding to it and showing WHY it was a strawman.
>
>
> >That's why it doesn't relate to any arguments of substance.
>
> Far more so than your salt argument.
>
>
> > There is nothing that says you cannot analyze and standardize whole herb strains.
>
> Well, actually, yes there is. No matter how much you try to do it, there is still far more
> inherent variability in the amount of active ingredient in an herb strain. It could depend on how
> the herb is grown, where it is grown, or just random chance. Extracting the active compound into a
> pure form that is measured and reproducible is far superior.
>
>
> >So from that point of view, extraction and standardization of digitalis is at best a nice
> >convenience to have.
>
> It is far more than a convenience, given the rather tricky nature of achieving the right dose of
> digitalis.
>
>
> >It doesn't make the foxglove prescriber a quack.
>
> Perhaps, but it does make the foxglove prescriber someone who is consciously choosing a manner of
> digitalis administration that is less efficacious and more risky.
There is no such person today, to my knowledge.
There are people who are aware that, say, Milk Thistle may be benefitial to some people, and still
consciously choose to make moot points about it.
> In article <[email protected]>, [email protected] (soft-
> eng) wrote:
>
> > Orac <[email protected]> wrote in message news:<orac-
> > [email protected]>...
> > > In article <[email protected]>, [email protected] (soft-
> > > eng) wrote:
> > >
> > > > "Rich Shewmaker" <[email protected]> wrote in message news:<h-KdnQ6LdPlBwpTdRVn-
> > > > [email protected]>...
> > > >
> > > > > It is interesting that you selected digitalis as your example. This drug is quite toxic in
> > > > > overdose, and the toxic dose is only slightly greater than
> > > >
> > > > Did you know an overdose of salt will kill you?
> > >
> > > But it would take a hell of a lot to do so in a person with normal kidney function.
> > >
> > >
> > > > Or that a little bit less than a fatal overdose would damage your brain? Or that overdoing
> > > > it even in normal usage would increase your blood pressure? And yet, if salt weren't
> > > > available at all, you would have many health problems from salt deprivation?
> > >
> > > The vast majority of people get more than adequate salt in their daily diet. Even vegans.
> > > Supplementation is rarely necessary or helpful.
> > >
> > >
> > > > Many everyday ingestibles are toxic in overdose.
> > >
> > > Straw man. The difference is that, in contrast to your other example, digitalis has a rather
> > > narrow range of efficacy. The range between an ineffective dose and a toxic dose is narrow and
> > > easily crossed. Moreover, its pharmacokinetics are such that it takes a long time to build up
> > > a therapeutic dose and a long time for it to be metabolized away when the toxic dose has been
> > > passed. Worse, there is a fair amount of person-to-person variation in its metabolism.
> > >
> > >
> > > > But Foxglove was actually IN USE by herbal dispensers before medicine in its modern form
> > > > acquired it.
> > > >
> > > > I am not saying standardization is not of benefit. Obviously it is. But that doesn't relate
> > > > to any arguments of substance in this thread.
> > >
> > > Yes it does. The whole point is that using digitalis in a pure, standardized form is
> > > inherently safer and more efficacious than relying on hit-and-miss dosing through the
> > > administration of foxglove leaves.
> >
> > Nobody said analysis and standardization is not of benefit. That's just a strawman you inserted
> > in the debate.
>
> Wrong. Your example of salt as an example of how "everyday substances are toxic in overdose" was
> the obvious strawman. I was merely responding to it and showing WHY it was a strawman.
>
>
> >That's why it doesn't relate to any arguments of substance.
>
> Far more so than your salt argument.
>
>
> > There is nothing that says you cannot analyze and standardize whole herb strains.
>
> Well, actually, yes there is. No matter how much you try to do it, there is still far more
> inherent variability in the amount of active ingredient in an herb strain. It could depend on how
> the herb is grown, where it is grown, or just random chance. Extracting the active compound into a
> pure form that is measured and reproducible is far superior.
>
>
> >So from that point of view, extraction and standardization of digitalis is at best a nice
> >convenience to have.
>
> It is far more than a convenience, given the rather tricky nature of achieving the right dose of
> digitalis.
>
>
> >It doesn't make the foxglove prescriber a quack.
>
> Perhaps, but it does make the foxglove prescriber someone who is consciously choosing a manner of
> digitalis administration that is less efficacious and more risky.
There is no such person today, to my knowledge.
There are people who are aware that, say, Milk Thistle may be benefitial to some people, and still
consciously choose to make moot points about it.