Hemopure (bovine plasma) booster



Flyer

Flyer

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Sep 20, 2004
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The powerful anemia drugs just keep on coming!

HBOCs are well known to cyclist---especially those with cancer recovery experience and Italian consultants.

On February 1, 2005 Biopure, a Cambridge Mass. drug company announced plans to market this new anemia product in South Africa--where it is now approved for use in adult surgical patients---humans beings.

You can bet that elite cyclists will be interested in a sample or clinical research supply.

This product, Hemapure (hemaglobin glutamer 250 bovine) is an oxygen therapeutic consisting of bovine hemaglobin formulated in a balanced salt solution.

It is compatable with all blood types (Hamilton or Armstrong?), whole rosters and is stable without refrigeration! (a Team PDM EPO problem from 1992)

This is an HBOC---and was used by the US Naval Medical Research Center. Naval personnel are often treated like athletes.

Hematocrit levels do not elevate---but oxygen boosting does increase tremendously.

http://www.corporate-ir.net/ireye/ir_site.zhtml?ticker=BPUR&sc...

Look for this product in a South African Pharmacy soon. Perhaps the 16 year old who went EPO positive last September will be first in line?
 
Is Hempure a newer and improved version of Actovegin, a product sued by USPO in the 2000 TDF and confirmed by Lance Armstrong on his own website in December 2000?

In 2000 Actovegin was only approved for use in animals so the UCI did not have it on the banned list in 2000. It was banned for 2001.


Lance also admitted to possessing insulin, but refused to identify the users due to medical privacy.

Peraflouracarbon is yet another HBOC which nearly killed Classic winner Mauro Gianetti on May 5th, 1998 during the Tour of Romandie. Mauro is now the manager of Chris Horner, USA #1 road cyclist.

Overdosing is no longer encouraged.
 
ElRamon said:
It's ok I've found it?
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Hemaglobin-based oxygen carrier

These products can be stored at room temperature for many months w/o loss of effectiveness, can be used on all blood types.

They do not promote kidney function (as EPO does) or require Iron supplements as steady EPO use may lead to, however, they increase the capacity of existing red blood cells.

When used in concert with other blood boosting methods and flow---medications, the results are stunning.

The very idea that a "clean athlete with a superior work ethic" could defeat a well-charged champion is the greatest myth of all.

The rider with the very best medical program, drugs & protocol combined with training, diet & rest will produce the great sustainable power. The rest is tactics and luck.

It ain't a breathing contest, rather it is a chemistry experiment.
 
Flyer said:
They do not promote kidney function (as EPO does)
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???

Epo is produced by the kidneys. People with many types of chronic kidney failure have low endogenous Epo levels and hence anaemia (because their stuffed kidneys are not producing it). They are treated with exogenous Epo to stop them being anaemic. The Epo does nothing to help or hinder their kidney function. Ditto for elite athletes using Epo - it does not "promote kidney function".
 
patch70 said:
???

Epo is produced by the kidneys. People with many types of chronic kidney failure have low endogenous Epo levels and hence anaemia (because their stuffed kidneys are not producing it). They are treated with exogenous Epo to stop them being anaemic. The Epo does nothing to help or hinder their kidney function. Ditto for elite athletes using Epo - it does not "promote kidney function".
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No affect on the adrenal glands?

That's precisely what Concini & Ferrari advise their patients. EPO is harmless and will not affect the kidney. Their clients believe this wholeheartedly. So too with Orange Juice consumption.

IGF-1 & iron supplementations factor into this game too, else blood chemistry goes wacky.

Sadly Marco Pantani is not here for us to debrief him on his personal yo-yo with anemia followed by too high hematocrit levels (29-57%) Does a decade of EPO supplementations retard adrenal function?

Some doctors believe it might---so too with the pituitary glands and HGH, testosterone, clomid and Nandrolone.

All these organs function fine in healthy people---supplementing has has short-term boost---followed by health issues if the habit goes too long.

Nobody has really studies this--no profit in knowing the truth--only the short term gains can be marketed.
 
Flyer said:
No affect on the adrenal glands?
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No. Apart from the potential complications of an excessively high haematocrit, Epo itself does not directly help or hinder renal or adrenal function.

Sadly Marco Pantani is not here for us to debrief him on his personal yo-yo with anemia followed by too high hematocrit levels (29-57%) Does a decade of EPO supplementations retard adrenal function?
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The problem with Marco was probably the development of anti-Epo antibodies. This led to the very low Hct that he had later because even his endogenous Epo couldn't function. This is an occasional complication of long-term Epo use that is getting less common with newer versions of Epo such as Aranesp (darbopoietin). However, regarding Marco, this is speculation as nobody is willing to publish this - even though it would be the first documented case of antibodies against Epo in an athlete.
 
patch70 said:
No. Apart from the potential complications of an excessively high haematocrit, Epo itself does not directly help or hinder renal or adrenal function.



The problem with Marco was probably the development of anti-Epo antibodies. This led to the very low Hct that he had later because even his endogenous Epo couldn't function. This is an occasional complication of long-term Epo use that is getting less common with newer versions of Epo such as Aranesp (darbopoietin). However, regarding Marco, this is speculation as nobody is willing to publish this - even though it would be the first documented case of antibodies against Epo in an athlete.
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The anti-epo antibodies where associated primarily with one preperation- eprex. Probably had to do with one of the diluent proteins. Aranesp is probably not the drug of choice as it is detecable and has a dramaticly longer half life than recombinant epo.
Epo has no effect on the adrenal galnd function.
 
I should add that hemopure is easily detectable by HPLC frmo urine samples up to 48 hours after usage.

Clin Chem. 2004 Apr;50(4):723-31. Epub 2004 Feb 05.

There are concerns with hemoglobin substitutes- Abdominal pain- potential anaphylaxis etc. Not major concerns for use in trauma situations but may hinder usage as a doping agent.

The uci has done preliminary testing for synthetic hemaglobins.
 
Perro Loco said:
Aranesp is probably not the drug of choice as it is detecable and has a dramaticly longer half life than recombinant epo.
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Actually, I was referring to using it in renal & haematology patients! ;)
 
patch70 said:
Actually, I was referring to using it in renal & haematology patients! ;)
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Darbopoietin offers only modest benefits over recombinant erythropoietin. Once weekly dosaging is often effective with Recom. erythropoietin and using darbopoietin once every two to three weeks is only a modest improvement. It ends up being a cost analysis - which ends up being cheaper. It is unclear if Darbopoietin will induce anti-epo antibodies- to date it apears to less likely though it's use is not as wide as rEpo. Incidentaly, Anti-epo antibodies are now seen much less secondary to a change in one of the diluent proteins in eprex.
N Engl J Med. 2004 Sep 30;351(14):1403-8.
 
Perro Loco said:
Darbopoietin offers only modest benefits over recombinant erythropoietin. Once weekly dosaging is often effective with Recom. erythropoietin and using darbopoietin once every two to three weeks is only a modest improvement. It ends up being a cost analysis - which ends up being cheaper. It is unclear if Darbopoietin will induce anti-epo antibodies- to date it apears to less likely though it's use is not as wide as rEpo. Incidentaly, Anti-epo antibodies are now seen much less secondary to a change in one of the diluent proteins in eprex.
N Engl J Med. 2004 Sep 30;351(14):1403-8.
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Edita Rumsas was in possession of Actovegin in July 2002. see the contents of her car boot at:

http://www.cyclingnews.com/news/?id=2002/sep02/sep13news

Jesus Manzano referred to both Actovegin & Hempure in his multi-week interviews re: doping products used at Team Kelme in 2003.

http://www.cyclingnews.com/news.php?id=news/2004/mar04/mar29news

What do we know about Hemassist, Hemoce, Neorecormon?
 
a few facts about hemassist

Administration of approximately 1000 mg/kg DCLHb was associated with transient arterial hypertension, gastrointestinal side effects, laboratory abnormalities, yellow skin discoloration, and hemoglobinuria. These observations point to opportunities for improvement in future synthetic hemoglobin design.
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Sounds like a great doping aid.

Neorecormon is a trade name for Recombinant epo.
Not familar with Hemoce- a quick look I think it's a plasma expander with suggested but for from proven effects similar to Actovegin.
 
Perro Loco said:
a few facts about hemassist

Sounds like a great doping aid.

Neorecormon is a trade name for Recombinant epo.
Not familar with Hemoce- a quick look I think it's a plasma expander with suggested but for from proven effects similar to Actovegin.
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Do you think that Lance's employer might inform both he and his physicans of any new drugs they are planning to market--or are developing with partners?

As a professional courtesy perhaps?

He's always testing new equipment--why not drugs?

http://www.bmsmi.com/press_releases/news102103.htm

This for a maximal vasodilation of the coronary arteries. If it works for couch pototos, why not athletes?

Can this add more boost than Viagra?
 
Perro Loco said:
a few facts about hemassist

Sounds like a great doping aid.

Neorecormon is a trade name for Recombinant epo.
Not familar with Hemoce- a quick look I think it's a plasma expander with suggested but for from proven effects similar to Actovegin.
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Its nice to see you all have an interst in these drugs.... i would hate to imagine for what reason.
 
closesupport said:
Its nice to see you all have an interst in these drugs.... i would hate to imagine for what reason.
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Just curious why pro cyclist are drawn to cow plasma and vasodilars.

Let's hope the USADA hearing transcripts will be released in full (doubtful) so that we could know the bloody details of that case. Bovine or human.
 
I'm ashamed to admit it, but I've been ingesting bovine mammary extract for several years now. I haven't noticed any increase in my aerobic capacity, but it sure does taste good on cereal.
 
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