In article <[email hidden]>,
Sharon Hope said:"Larry" <[email hidden]> wrote in message
news:[email hidden]...
Quoted message said:<snip>
Quoted message said:Let's put it this way. If someone has a hx of heart disease and they have
high LDL cholesterol (and especially if they have low or medium HDL), one
has to have a way to keep the coronary arteries from building enough
plaque to cause a clot to cause an MI. If you can find another way to do
that? Great.
<snip>
Quoted message said:Larry E.
Quoted message said:Apparently you haven't been watching the studies (e.g., via PubMed
abstracts) that are somewhat consistently showing that it is not the
cholesterol reduction that is preventing the coronary arteries (only in
middle-aged white males with high heart attack risk, BTW) from "building
enough plaque to cause a clot to cause an MI."
Quoted message said:It is an unintended anti-inflammatory side-effect of statins that is now
fairly universally thought to do that.
I do not know how universal this is, but there certainly
is this opinion, and that it is C-reactive protein which
is the indication of inflammation. Again, this is something
which I have read.
A previous doctor (now retired) who tried to get me on
statins asked to have a followup done on something else,
and I asked him to include C-reactive protein in the test.
He asked why, and I told him frankly that if it was high,
I might reconsider taking statins. I am still not taking
statins.
Quoted message said:The cholesterol forms on the weakened spot in the artery to form a
high-pressure bandage. Without the protection, there can be a failure of
the artery wall. (Which is what was seen during early statin testing with
dogs - hemorrhagic stroke.)
This is one of the reasons why cholesterol is necessary.
Quoted message said:Without the inflammation, the cholesterol does not form plaque.
There is probably always SOME inflammation, and it there
is LOTS of LDL cholesterol of the "wrong" type, the danger
does go up, but all the problems need to be simultaneously
considered, and all the effects. This is NOT being done
by the medical profession or their researchers.
--
This address is for information only. I do not claim that these views
are those of the Statistics Department or of Purdue University.
Herman Rubin, Department of Statistics, Purdue University
[email hidden] Phone: (765)494-6054 FAX: (765)494-0558