Agree tires make a big difference in overall ride quality. I think tires have different rolling resistance values also, which may be more important than the weight savings in speed.
Michelin slicks do seem to be comfortable with good road feel (I've got Pro Race on now), but maybe not as durable as the Conti 3000s, in my experience. I've never had a puncture with the Conti's, but have cut several Michelin slicks through. Maybe just my bad luck with the French tires.
Agree on the 100-105 psi. Used to pump 'em up to the sidewall max, 120 or more, but have found better ride at lower pressures with no noticeable increase in rolling resistance. Michelin Pro Race says 87-116 psi on the sidewall, so 100 psi is right in the middle. Best pressure probably depends on weight also, since the contact patch expands with weight.
Dan