Somehow my previous message on this got lost. The Gaist Paper was interesting.
I think Sharon was referring to a different Muldoon paper:
Effects of lovastatin on cognitive function and psychological well-being**1
Matthew F. Muldoon MD, MPH, a, Steven D. Barger PhDb, Christopher M. Ryan
PhDc, Janine D. Flory PhDd, John P. Lehoczky PhDe, Karen A. Matthews PhDc and
Stephen B. Manuck PhDd
a Center for Clinical Pharmacology (MFM), University of Pittsburgh School of
Medicine, Pittsburgh, Pennsylvania USA
c Department of Psychiatry (CMR, KAM), University of Pittsburgh School of
Medicine, Pittsburgh, Pennsylvania, USA
b Department of Psychology (SDB), Northern Arizona University, Flagstaff,
Arizona, USA
d Behavioral Physiology Laboratory (JDF, SBM), Department of Psychology,
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
e Department of Statistics (JPL), Carnegie Mellon University, Pittsburgh,
Pennsylvania, USA
Received 17 May 1999; revised 6 January 2000; accepted 6 January 2000.
Available online 5 May 2000.
Abstract
PURPOSE: Animal research and cross-sectional studies suggest that serum lipid
concentrations may influence cognitive function, mood, and behavior, but few
clinical trials have studied these effects.
SUBJECTS AND METHODS: In this double-blind investigation, 209 generally
healthy adults with a serum low-density-lipoprotein (LDL) cholesterol level of
160 mg/dL or higher were randomly assigned to 6-month treatment with
lovastatin (20 mg) or placebo. Assessments of neuropsychological performance,
depression, hostility, and quality of life were conducted at baseline and at
the end of the treatment period. Summary effect sizes were estimated as z
scores on a standard deviation (SD) scale.
RESULTS: Placebo-treated subjects improved between baseline and posttreatment
periods on neuropsychological tests in all five performance domains,
consistent with the effects of practice on test performance (all P <0.04),
whereas those treated with lovastatin improved only on tests of memory recall
(P = 0.03). Comparisons of the changes in performance between placebo- and
lovastatin-treated subjects revealed small, but statistically significant,
differences for tests of attention (z score = 0.18; 95% confidence interval
(CI), 0.06 to 0.31; P = 0.005) and psychomotor speed (z score = 0.17; 95% CI,
0.05 to 0.28; P = 0.004) that were consistent with greater improvement in the
placebo group. Psychological well-being, as measured several ways, was not
affected by lovastatin.
CONCLUSION: Treatment of hypercholesterolemia with lovastatin did not cause
psychological distress or substantially alter cognitive function. Treatment
did result in small performance decrements on neuropsychological tests of
attention and psychomotor speed, the clinical importance of which is
uncertain.
Bill
"Pete Connors" <[email hidden]> wrote in message
news:[email hidden]...
Quoted message said:Bill
The Muldoon paper is at
http://bmj.bmjjournals.com/cgi/content/full/322/7277/11
and the Gaist paper at
http://213.4.18.135/87.pdf
Cheers, PeteC
Bill said:
"Sharon Hope" <[email hidden]> wrote in message
news:[email hidden]...
Quoted message said:Bill,
Both are readily available on the net for a nominal fee - far less than
any
Quoted message said:Quoted message said:Quoted message said:one of the over 52 appointments with specialists and diagnostic clinical
tests my husband went through last year. I invite you to purchase the
full
Quoted message said:Quoted message said:Quoted message said:study and evaluate it yourself.
I am unable to publish a copy in full when it is available for a fee, and
any quote I pull out will be immediately second-guessed by those who are
threatened by the idea that some people's lives, health, and economic
well-being have been destroyed by these drugs.
I will try to obtain a copy. In the meantime, in my view, your contention
that
Quoted message said:Quoted message said:statins are known to have a negative cognitive impact remains uproven.
(Which,
Quoted message said:Quoted message said:of course, is different than incorrect.) Note, I have changed the subject
so
Quoted message said:Quoted message said:this discussion does not get lost in others.
Bill