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What percentage of a cholesterol decrease can be attributed to statins ?

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General fitness, health and nutrition
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4 October 2003
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2 November 2003
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Joe Smigiel
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  1. I had a heart attack June 9th, 3xCABG on June 13th, and am feeling
    pretty good now. I'm 49 and male with a history of CAD in my family
    (older brother 5xCABG, father 3XCABG, paternal uncles all with MIs,
    CAD). I went through a hospital cardiac rehab regimen in about 4 weeks
    time this summer and have increased my exercise rate about 25-30% since
    graduating from the program.

    My cardiologist has me on Lipitor 10mg/day as well as metaprolol,
    Altace, aspirin, and a daily multivitamin. The last time checked &
    several years before the heart attack my cholesterol was 202. Last
    month it was 116 with the hdl/ldl ratio about 3.5. Yesterday I had
    another blood test and the total cholesterol was less than 100, hdl @
    27. (Glucose 88, BP 90/58 which was low, usually around 100/70.)

    Since surgery I've done some lifestyle changes including quitting
    smoking (was 1 1/2 packs per day for 32 years), continuing to exercise
    5-6 times per week and I have changed my diet considerably. I'm eating
    oats instead of eggs for breakfast, probably have one meal with lean
    meat daily (usually chicken or lean pork) and try to do a vegetarian
    meal per day. I've switched to mostly non- or low-fat, low-salt foods
    and am doing more fruits, veggies, fish and nuts, olive oil. etc., and I
    haven't had a cup of regular coffee since the cardiac event. I'm still
    about a 20 pounds overweight (although not obese) even with the
    increased exercise and diet changes. I've been trying to shed the extra
    weight since April but have only lost about 8 pounds total. (I figure
    the exclusion of nicotine and caffeine have probably affected my
    metabolic rate and helped prevent some weight loss. I could do fewer
    carbs...)

    My question relates to how much of the drop in cholesterol could be
    attributed to the statin? I'd like to get off the drug if I could and
    am wondering if the diet and lifestyle changes are the main cause of the
    lowered cholesterol or if it is the Lipitor? Any studies out there that
    have shown what percentage of cholesterol loss can be attributed to the
    various factors including statins?

    I'm curious and want to get off the statin because of the reported side
    effects. I think I've suffered "pump head" and am currently undergoing
    testing for losses in cognitive ability, but I've also read statins can
    produce similar effects.

    Thanks for any info or pointers.

    Joe

    (replace the "o" in the email address with an "e" to reply to me
    directly)

  2. "Joe Smigiel" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    My question relates to how much of the drop in cholesterol could be
    attributed to the statin? I'd like to get off the drug if I could and
    am wondering if the diet and lifestyle changes are the main cause of the
    lowered cholesterol or if it is the Lipitor? Any studies out there that
    have shown what percentage of cholesterol loss can be attributed to the
    various factors including statins?

    I'm curious and want to get off the statin because of the reported side
    effects. I think I've suffered "pump head" and am currently undergoing
    testing for losses in cognitive ability, but I've also read statins can
    produce similar effects.

    Thanks for any info or pointers.

    Joe

    I'm not a Dr. and hopefully someone more knowledgeable than I am will respond.
    I'm not aware of any such studies - showing the results of statins vs. diet
    vs. exercise - , but they would probably not be very meaningful anyway because
    the results would vary with the type of diet change (the particular before and
    after diet), exercise change, particular statin and dose, and the individual.
    What is known is that in a broad range of individuals statins reduce LDL
    cholesterol and reduce the risk of cardiovascular "events". However, if you
    are concerned you could talk to your Dr. about going off the Lipitor for a
    period of time and see what happens. That is the only real way of telling.

    As far as I know, however, the cognitive effects of statins are not
    established and also you are on a very low dose. So I think the risk there is
    very small. Also I note that your HDL is very low at 27. Exercise can increase
    this. You said you exercise, but you did not mention how long or how
    vigorously. You might also talk to your Dr. about taking a small amount of
    niacin to improve your HDL. Also, a lot of people recommend fish oil capsules
    for heart patients in general.

    Bill

  3. Just came across this possibly related article:

    Bill

    ___________________

    Statin Therapy Slows Alzheimer's in Small Study

    LONDON (Reuters Health) Sept 22 - Simvastatin significantly slowed disease
    progression in Alzheimer's patients, according to the findings of a small
    German study released on Monday.

    Professor Konrad Beyreuther, of the University of Heidelberg, Germany said 44
    patients were randomized to receive either simvastatin or placebo in a 26-week
    double blind study.

    He told the 16th European College of Neuropsychopharmacology conference in
    Prague that by the end of study, there was a significant difference in the
    patients' average Mini-Mental Status Exam (MMSE) scores.

    In the treatment arm, the slowest rate of disease progression was seen in
    patients with moderate rather than severe Alzheimer's disease, suggesting a
    narrow therapeutic window. He said other studies by his group using guinea
    pigs were also encouraging.

    Several lines of evidence have raised hopes for statin therapy against
    Alzheimer's. Cholesterol metabolism and the disease are genetically linked.
    The apoE4 gene is associated with higher cholesterol levels and has been shown
    to increase the risk of developing the disease three to seven-fold.

    Experimental suppression of cholesterol by statins reduces the formation of
    the short and long forms of amyloid beta. Epidemiological studies have also
    shown that statin therapy reduced the relative risk of Alzheimer's threefold.

    Beyreuther said: "Our hopes go towards brain cholesterol lowering therapies
    because (these) studies, our experiments in cells and animals, and our initial
    clinical trial suggest that treatment with cholesterol-lowering drugs reduces
    amyloid beta production and disease progression."

    But he cautioned: "Long term trials in larger population will have to clarity
    whether statins indeed are able to slow the progression of cognitive symptoms
    in Alzheimer's disease."

  4. Joe Smigiel said:

    I had a heart attack June 9th, 3xCABG on June 13th, and am feeling
    pretty good now. I'm 49 and male with a history of CAD in my family
    (older brother 5xCABG, father 3XCABG, paternal uncles all with MIs,
    CAD). I went through a hospital cardiac rehab regimen in about 4 weeks
    time this summer and have increased my exercise rate about 25-30% since
    graduating from the program.

    My cardiologist has me on Lipitor 10mg/day as well as metaprolol,
    Altace, aspirin, and a daily multivitamin. The last time checked &
    several years before the heart attack my cholesterol was 202. Last
    month it was 116 with the hdl/ldl ratio about 3.5. Yesterday I had
    another blood test and the total cholesterol was less than 100, hdl @
    27. (Glucose 88, BP 90/58 which was low, usually around 100/70.)

    Since surgery I've done some lifestyle changes including quitting
    smoking (was 1 1/2 packs per day for 32 years), continuing to exercise
    5-6 times per week and I have changed my diet considerably. I'm eating
    oats instead of eggs for breakfast, probably have one meal with lean
    meat daily (usually chicken or lean pork) and try to do a vegetarian
    meal per day. I've switched to mostly non- or low-fat, low-salt foods
    and am doing more fruits, veggies, fish and nuts, olive oil. etc., and I
    haven't had a cup of regular coffee since the cardiac event. I'm still
    about a 20 pounds overweight (although not obese) even with the
    increased exercise and diet changes. I've been trying to shed the extra
    weight since April but have only lost about 8 pounds total. (I figure
    the exclusion of nicotine and caffeine have probably affected my
    metabolic rate and helped prevent some weight loss. I could do fewer
    carbs...)

    My question relates to how much of the drop in cholesterol could be
    attributed to the statin? I'd like to get off the drug if I could and
    am wondering if the diet and lifestyle changes are the main cause of the
    lowered cholesterol or if it is the Lipitor? Any studies out there that
    have shown what percentage of cholesterol loss can be attributed to the
    various factors including statins?

    I'm curious and want to get off the statin because of the reported side
    effects. I think I've suffered "pump head" and am currently undergoing
    testing for losses in cognitive ability, but I've also read statins can
    produce similar effects.

    Thanks for any info or pointers.

    Joe

    (replace the "o" in the email address with an "e" to reply to me
    directly)

    Your HDL is very low. Above you state your TC is under 100 but I think you
    mean LDL?

    Have you cut out refined carbohydrates? I think cutting out refined carbs
    can help you raise HDL. Of course exercise can also help. The type of
    exercise in how vigorous, length of time, and how often are all factors in
    raising HDL. Some believe that fatty fish like salmon, sardines, and
    herring can also help your HDL, and fish oil capsules as well. Olive oil
    may help and eating nuts, too. Walnuts contain the omega 3's. Certain nuts
    are high in monosaturated fat like hazelnuts, almonds, pecans, and
    macadamia nuts.

    You don't need meat every day, regardless of whether it's chicken or pork.
    Consider a mediterranean style diet and replacing some of your meat meals
    with beans and rice -- brown rice. Consider having whole wheat pasta.
    Consider more vegetarian type meals and eating small portions with snacks
    such as one ounce of nuts along with a piece of fruit. You don't have to
    feel full after eating a meal. I think one of the biggest mistakes people
    make is a need to feel full after having a meal. Walk away from the table
    with room for more. About two hours or so later, have some nuts and a piece
    of fruit.

    Consider getting "Eat, Drink, and be Healthy" by Dr. Walter Willett.

    I am not a doctor, just someone like you trying to do the right thing.

    Mel

  5. "Bill" <[email hidden]> wrote in message news:<[email hidden]>...

    Quoted message said:

    "Joe Smigiel" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    My question relates to how much of > > As far as I know, however, the cognitive effects of statins are not


    established and also you are on a very low dose. > Bill

    They are exceedingly well established in a clinical study reported
    only a few months ago. Do a google search on this newsgroup for the
    reference. What this study showed was that 100% of the patients put
    on a statin for a period of six months suffered a drop in IQ. The
    mean of the placebo control group showed a small increase in IQ as to
    be expected due to practice taking the test six months before at the
    start of the study.

    You need to do your homework better Bill.

  6. "M. Schwartz" wrote:
    (snip)

    Your HDL is very low. Above you state your TC is under 100 but I think you

    Quoted message said:

    mean LDL?

    Have you (snip)

    Quoted message said:

    Mel

    Uh no. I meant what I said. Total cholesterol under 100. I'm aware there
    are other things I could be doing which might lower it even further, but why?
    My question basically is asking if I had fairly low cholesterol to begin with
    (202) and have since lowered it considerably (under 100), can I get away with
    continuing the lifestyle changes and at the same time cutting out Lipitor?
    Does Lipitor account for perhaps 10% of the decrease, or 50%, or 90%...?

    Joe

  7. In my case, Zocor was solely responsible for a significant lowering of
    my cholesterol. Diet and exercise did not help at all, in fact my
    cholesterol kept rising until I took Zocor.

    --

    Herb
    Boulder, CO

    "Joe Smigiel" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    I had a heart attack June 9th, 3xCABG on June 13th, and am feeling
    pretty good now. I'm 49 and male with a history of CAD in my family
    (older brother 5xCABG, father 3XCABG, paternal uncles all with MIs,
    CAD). I went through a hospital cardiac rehab regimen in about 4


    weeks

    Quoted message said:

    time this summer and have increased my exercise rate about 25-30%


    since

    Quoted message said:

    graduating from the program.

    My cardiologist has me on Lipitor 10mg/day as well as metaprolol,
    Altace, aspirin, and a daily multivitamin. The last time checked &
    several years before the heart attack my cholesterol was 202. Last
    month it was 116 with the hdl/ldl ratio about 3.5. Yesterday I had
    another blood test and the total cholesterol was less than 100, hdl @
    27. (Glucose 88, BP 90/58 which was low, usually around 100/70.)

    Since surgery I've done some lifestyle changes including quitting
    smoking (was 1 1/2 packs per day for 32 years), continuing to exercise
    5-6 times per week and I have changed my diet considerably. I'm


    eating

    Quoted message said:

    oats instead of eggs for breakfast, probably have one meal with lean
    meat daily (usually chicken or lean pork) and try to do a vegetarian
    meal per day. I've switched to mostly non- or low-fat, low-salt foods
    and am doing more fruits, veggies, fish and nuts, olive oil. etc., and


    I

    Quoted message said:

    haven't had a cup of regular coffee since the cardiac event. I'm


    still

    Quoted message said:

    about a 20 pounds overweight (although not obese) even with the
    increased exercise and diet changes. I've been trying to shed the


    extra

    Quoted message said:

    weight since April but have only lost about 8 pounds total. (I figure
    the exclusion of nicotine and caffeine have probably affected my
    metabolic rate and helped prevent some weight loss. I could do fewer
    carbs...)

    My question relates to how much of the drop in cholesterol could be
    attributed to the statin? I'd like to get off the drug if I could and
    am wondering if the diet and lifestyle changes are the main cause of


    the

    Quoted message said:

    lowered cholesterol or if it is the Lipitor? Any studies out there


    that

    Quoted message said:

    have shown what percentage of cholesterol loss can be attributed to


    the

    Quoted message said:

    various factors including statins?

    I'm curious and want to get off the statin because of the reported


    side

    Quoted message said:

    effects. I think I've suffered "pump head" and am currently


    undergoing

    Quoted message said:

    testing for losses in cognitive ability, but I've also read statins


    can

    Quoted message said:

    produce similar effects.

    Thanks for any info or pointers.

    Joe

    (replace the "o" in the email address with an "e" to reply to me
    directly)

  8. Joe Smigiel said:

    "M. Schwartz" wrote:
    (snip)

    Your HDL is very low. Above you state your TC is under 100 but I think you

    Quoted message said:

    mean LDL?

    Have you (snip)

    Quoted message said:

    Mel

    Uh no. I meant what I said. Total cholesterol under 100. I'm aware there
    are other things I could be doing which might lower it even further, but why?
    My question basically is asking if I had fairly low cholesterol to begin with
    (202) and have since lowered it considerably (under 100), can I get away with
    continuing the lifestyle changes and at the same time cutting out Lipitor?
    Does Lipitor account for perhaps 10% of the decrease, or 50%, or 90%...?

    Joe

    Sorry, just noticed you were stating HDL/LDL ratio.

    It's pretty hard to know how much effect your Lipitor has on lowering the
    TC or LDL. I would guess a 10 mg dose of Liptor is reducing your
    cholesterol by around 30 percent.

    You could stop taking the drug and see how it goes. Your numbers are good
    except for that HDL of 27 which is theoretically quite bad. If you do
    decide to stop the drug and experiment, I would suggest following a diet
    that includes chicken 2 or 3 times a week, salmon twice a week, beans and
    rice at least once a week, a meat substitute like Lightlife's Gimme Lean
    that can be used to make meatballs. Those are suggestions for dinner. Lunch
    should be sardines at least once a week, veggie burger at least once a
    week, ratatoulle twice a week, turkey breast once a week, porcini mushroom
    and barley risotta (from Dr. Willet's book) - lunch menus are not
    practical if you have to work outside your home :-)

    You really should get Dr. Willett's book and follow his food pyramid - just
    my opinion.

    One more very important thing, when taking a statin drug, you should
    definitely be taking a Co-Q10 supplement. Statin drugs prevent the body
    from manufacturing this much needed nutrient. A daily dose of at least 100
    mg is highly recommended - not the powdered capsule but the softgel.

    Mel

  9. Herb said:

    In my case, Zocor was solely responsible for a significant lowering of
    my cholesterol. Diet and exercise did not help at all, in fact my
    cholesterol kept rising until I took Zocor.

    Did you cut out all refined carbohydrates? I take 10 mg of Zocor and it did
    reduce my cholesterol by around 25 percent. However, when I cut out refined
    carbs and made other changes to my diet, my total cholesterol dropped even
    more and my LDL dropped from around 98 to 81.

    Mel

  10. Joe Smigiel <[email hidden]> wrote in part:

    Quoted message said:

    Does Lipitor account for perhaps 10% of the decrease, or 50%, or 90%...?

    The data I've seen show that a statin reduces cholesterol much more than the
    reduction achieved by diet alone, for most people. In other words, the statin
    probably accounts for more than 50% of the reduction, possibly much more than
    50%.
    --
    Jim Chinnis Warrenton, Virginia, USA

  11. "Jim Chinnis" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    Joe Smigiel <[email hidden]> wrote in part:

    Quoted message said:

    Does Lipitor account for perhaps 10% of the decrease, or 50%, or 90%...?

    The data I've seen show that a statin reduces cholesterol much more than


    the

    Quoted message said:

    reduction achieved by diet alone, for most people. In other words, the


    statin

    Quoted message said:

    probably accounts for more than 50% of the reduction, possibly much more


    than

    Quoted message said:

    50%.
    --
    Jim Chinnis Warrenton, Virginia, USA

    Some Data on Low Cholesterol Diet - No Statins taken.
    Same lab used for both tests - VA Medical Center in Martinsburg, WV. I will
    be having my blood tested every six months so I should get some good long
    term data.
    I also get some form of exercise every day.
    See Below:

    As you can see the total Cholesterol went up but look at the breakdown and
    ratios.
    In addition to being on low carbs, I eat fish at least three times a week,
    eat LOTS of vegetables, cook using olive oil and drink home made dry red
    wine every day. Typical breakfast is eggs and sausage and meat is either
    fish, chicken, pork or beef - either pan fried in Olive oil or baked.

    Started Low Carb diet in May 2003
    Age: 58
    Height 6 foot 1/2 inch

    Date 7-Mar 17-Sep

    Weight 230 207
    Total Cholesterol 194 229
    Triglycerides 65 31
    HDL 58 86
    LDL 122 136.8

    Ratio of Total / HDL 3.34 2.66
    Ratio of Tri / HDL 1.12 .360

  12. Joe Smigiel said:

    I had a heart attack June 9th, 3xCABG on June 13th, and am feeling
    pretty good now. I'm 49 and male with a history of CAD in my family
    (older brother 5xCABG, father 3XCABG, paternal uncles all with MIs,
    CAD). I went through a hospital cardiac rehab regimen in about 4 weeks
    time this summer and have increased my exercise rate about 25-30% since
    graduating from the program.

    My cardiologist has me on Lipitor 10mg/day as well as metaprolol,
    Altace, aspirin, and a daily multivitamin. The last time checked &
    several years before the heart attack my cholesterol was 202. Last
    month it was 116 with the hdl/ldl ratio about 3.5.

    You probably mean LDL/HDL ratio.

    Quoted message said:

    Yesterday I had
    another blood test and the total cholesterol was less than 100, hdl @
    27. (Glucose 88, BP 90/58 which was low, usually around 100/70.)

    Your HDL needs to be higher. More exercise should help that.

    Quoted message said:


    Since surgery I've done some lifestyle changes including quitting
    smoking (was 1 1/2 packs per day for 32 years),

    Good.

    Quoted message said:

    continuing to exercise
    5-6 times per week

    This needs to be aerobic for at least 30 minutes daily preferably before
    supper.

    Quoted message said:

    and I have changed my diet considerably. I'm eating
    oats instead of eggs for breakfast, probably have one meal with lean
    meat daily (usually chicken or lean pork) and try to do a vegetarian
    meal per day. I've switched to mostly non- or low-fat, low-salt foods
    and am doing more fruits, veggies, fish and nuts, olive oil. etc., and I
    haven't had a cup of regular coffee since the cardiac event. I'm still
    about a 20 pounds overweight (although not obese) even with the
    increased exercise and diet changes. I've been trying to shed the extra
    weight since April but have only lost about 8 pounds total. (I figure
    the exclusion of nicotine and caffeine have probably affected my
    metabolic rate

    This does more to increase appetite than to lower metabolic rate.

    Quoted message said:

    and helped prevent some weight loss. I could do fewer
    carbs...)

    Carbs don't cause obesity.

    Quoted message said:

    My question relates to how much of the drop in cholesterol could be
    attributed to the statin?

    Much of it could be from the statin.

    Quoted message said:

    I'd like to get off the drug if I could and
    am wondering if the diet and lifestyle changes are the main cause of the
    lowered cholesterol or if it is the Lipitor?

    Ask your doctor about going without it for a couple months to see.

    Quoted message said:

    Any studies out there that
    have shown what percentage of cholesterol loss can be attributed to the
    various factors including statins?

    Population averages don't predict individual experiences very well.

    Quoted message said:


    I'm curious and want to get off the statin because of the reported side
    effects. I think I've suffered "pump head" and am currently undergoing
    testing for losses in cognitive ability, but I've also read statins can
    produce similar effects.

    Thanks for any info or pointers.

    Joe

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com

  13. M. Schwartz said:
    Joe Smigiel said:

    "M. Schwartz" wrote:
    (snip)

    Your HDL is very low. Above you state your TC is under 100 but I think you

    Quoted message said:

    mean LDL?

    Have you (snip)

    Quoted message said:

    Mel

    Uh no. I meant what I said. Total cholesterol under 100. I'm aware there
    are other things I could be doing which might lower it even further, but why?
    My question basically is asking if I had fairly low cholesterol to begin with
    (202) and have since lowered it considerably (under 100), can I get away with
    continuing the lifestyle changes and at the same time cutting out Lipitor?
    Does Lipitor account for perhaps 10% of the decrease, or 50%, or 90%...?

    Joe

    Sorry, just noticed you were stating HDL/LDL ratio.

    It's pretty hard to know how much effect your Lipitor has on lowering the
    TC or LDL. I would guess a 10 mg dose of Liptor is reducing your
    cholesterol by around 30 percent.

    You could stop taking the drug and see how it goes. Your numbers are good
    except for that HDL of 27 which is theoretically quite bad. If you do
    decide to stop the drug and experiment, I would suggest following a diet
    that includes chicken 2 or 3 times a week, salmon twice a week, beans and
    rice at least once a week, a meat substitute like Lightlife's Gimme Lean
    that can be used to make meatballs. Those are suggestions for dinner. Lunch
    should be sardines at least once a week, veggie burger at least once a
    week, ratatoulle twice a week, turkey breast once a week, porcini mushroom
    and barley risotta (from Dr. Willet's book) - lunch menus are not
    practical if you have to work outside your home :-)

    You really should get Dr. Willett's book and follow his food pyramid - just
    my opinion.

    One more very important thing, when taking a statin drug, you should
    definitely be taking a Co-Q10 supplement. Statin drugs prevent the body
    from manufacturing this much needed nutrient. A daily dose of at least 100
    mg is highly recommended - not the powdered capsule but the softgel.

    Mel


    What does Co-Q10 do? Can I get it from food sources?

    John Merlano

  14. MD/PhD said:
    Joe Smigiel said:

    I had a heart attack June 9th, 3xCABG on June 13th, and am feeling
    pretty good now. I'm 49 and male with a history of CAD in my family
    (older brother 5xCABG, father 3XCABG, paternal uncles all with MIs,
    CAD). I went through a hospital cardiac rehab regimen in about 4 weeks
    time this summer and have increased my exercise rate about 25-30% since
    graduating from the program.

    My cardiologist has me on Lipitor 10mg/day as well as metaprolol,
    Altace, aspirin, and a daily multivitamin. The last time checked &
    several years before the heart attack my cholesterol was 202. Last
    month it was 116 with the hdl/ldl ratio about 3.5.

    You probably mean LDL/HDL ratio.

    Quoted message said:

    Yesterday I had
    another blood test and the total cholesterol was less than 100, hdl @
    27. (Glucose 88, BP 90/58 which was low, usually around 100/70.)

    Your HDL needs to be higher. More exercise should help that.

    Quoted message said:


    Since surgery I've done some lifestyle changes including quitting
    smoking (was 1 1/2 packs per day for 32 years),

    Good.

    Quoted message said:

    continuing to exercise
    5-6 times per week

    This needs to be aerobic for at least 30 minutes daily preferably before
    supper.

    Quoted message said:

    and I have changed my diet considerably. I'm eating
    oats instead of eggs for breakfast, probably have one meal with lean
    meat daily (usually chicken or lean pork) and try to do a vegetarian
    meal per day. I've switched to mostly non- or low-fat, low-salt foods
    and am doing more fruits, veggies, fish and nuts, olive oil. etc., and I
    haven't had a cup of regular coffee since the cardiac event. I'm still
    about a 20 pounds overweight (although not obese) even with the
    increased exercise and diet changes. I've been trying to shed the extra
    weight since April but have only lost about 8 pounds total. (I figure
    the exclusion of nicotine and caffeine have probably affected my
    metabolic rate

    This does more to increase appetite than to lower metabolic rate.

    Quoted message said:

    and helped prevent some weight loss. I could do fewer
    carbs...)

    Carbs don't cause obesity.

    Doesn't eating refined carbs contribute to gaining weight?

    John Merlano

    Quoted message said:


    Quoted message said:

    My question relates to how much of the drop in cholesterol could be
    attributed to the statin?

    Much of it could be from the statin.

    Quoted message said:

    I'd like to get off the drug if I could and
    am wondering if the diet and lifestyle changes are the main cause of the
    lowered cholesterol or if it is the Lipitor?

    Ask your doctor about going without it for a couple months to see.

    Quoted message said:

    Any studies out there that
    have shown what percentage of cholesterol loss can be attributed to the
    various factors including statins?

    Population averages don't predict individual experiences very well.

    Quoted message said:


    I'm curious and want to get off the statin because of the reported side
    effects. I think I've suffered "pump head" and am currently undergoing
    testing for losses in cognitive ability, but I've also read statins can
    produce similar effects.

    Thanks for any info or pointers.

    Joe

  15. "Dr. Andrew B. Chung, MD/PhD" schrieb:

    Quoted message said:


    Joe Smigiel wrote:


    [...]

    Quoted message said:
    Quoted message said:

    and helped prevent some weight loss. I could do fewer
    carbs...)

    Carbs don't cause obesity.

    A growing number of scientists will disagree with you on that. However
    that may be, cutting out most carbs will cause a vast majority of obese
    people to lose weight. In addition, it offers a whole host of other
    health benefits like reduced bloodpressure and lower triglcerides. If
    you are interested in how this works, I'd recommend the book "Protein
    Power" by Michael and Mary Eades to you.

    Thorsten

    --
    "Nothing in biology makes sense, except in the light of evolution"

    (Theodosius Dobzhansky)

  16. "James" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    "Bill" <[email hidden]> wrote in message


    news:<[email hidden]>...

    Quoted message said:
    Quoted message said:

    "Joe Smigiel" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    My question relates to how much of > > As far as I know, however, the


    cognitive effects of statins are not

    Quoted message said:
    Quoted message said:

    established and also you are on a very low dose. > Bill

    They are exceedingly well established in a clinical study reported
    only a few months ago. Do a google search on this newsgroup for the
    reference. What this study showed was that 100% of the patients put
    on a statin for a period of six months suffered a drop in IQ. The
    mean of the placebo control group showed a small increase in IQ as to
    be expected due to practice taking the test six months before at the
    start of the study.

    You need to do your homework better Bill.

    Could you be so kind as to provide the reference.

    Bill

  17. John Merlano said:
    M. Schwartz said:
    Joe Smigiel said:

    "M. Schwartz" wrote:
    (snip)

    Your HDL is very low. Above you state your TC is under 100 but I think you

    > mean LDL?
    >
    > Have you (snip)

    > Mel

    Uh no. I meant what I said. Total cholesterol under 100. I'm aware there
    are other things I could be doing which might lower it even further, but why?
    My question basically is asking if I had fairly low cholesterol to begin with
    (202) and have since lowered it considerably (under 100), can I get away with
    continuing the lifestyle changes and at the same time cutting out Lipitor?
    Does Lipitor account for perhaps 10% of the decrease, or 50%, or 90%...?

    Joe

    Sorry, just noticed you were stating HDL/LDL ratio.

    It's pretty hard to know how much effect your Lipitor has on lowering the
    TC or LDL. I would guess a 10 mg dose of Liptor is reducing your
    cholesterol by around 30 percent.

    You could stop taking the drug and see how it goes. Your numbers are good
    except for that HDL of 27 which is theoretically quite bad. If you do
    decide to stop the drug and experiment, I would suggest following a diet
    that includes chicken 2 or 3 times a week, salmon twice a week, beans and
    rice at least once a week, a meat substitute like Lightlife's Gimme Lean
    that can be used to make meatballs. Those are suggestions for dinner. Lunch
    should be sardines at least once a week, veggie burger at least once a
    week, ratatoulle twice a week, turkey breast once a week, porcini mushroom
    and barley risotta (from Dr. Willet's book) - lunch menus are not
    practical if you have to work outside your home :-)

    You really should get Dr. Willett's book and follow his food pyramid - just
    my opinion.

    One more very important thing, when taking a statin drug, you should
    definitely be taking a Co-Q10 supplement. Statin drugs prevent the body
    from manufacturing this much needed nutrient. A daily dose of at least 100
    mg is highly recommended - not the powdered capsule but the softgel.

    Mel


    What does Co-Q10 do? Can I get it from food sources?

    John Merlano

    It is required for energy production. A deficiency of coenzyme Q10 is
    associated with impairment of myocardial function, with liver dysfunction
    and with myopathies (including cardiomyopathy and congestive heart
    failure).

    It is a naturally occurring nutrient normally present in every cell in the
    body, and also available through foods (especially fish and meats,
    particularly organ meats). The body makes CoQ-10, but many people probably
    don't make it very well, due to the highly complicated biochemical process
    required for its production. HMG CoA reductance inhibitors (statins) block
    the endogenous biosynthesis of an essential cofactor, coenzyme Q10.

    What that means is people taking a statin drug have CoQ-10 blocked from
    being made in the body. Therefore, it is advisable to supplement with at
    least 100 mg of the softgel form. There are two kinds of CoQ-10: capsule
    and softgel. For getting the most absorption of CoQ-10, it must have some
    form of fat to aid the process. Capsules are in a powdered form and need a
    fatty meal to help the absorption process while the softgel comes in an oil
    base to provide the needed fat and help better absorb more of the nutrient.

    Mel

  18. Thorsten Schier said:

    "Dr. Andrew B. Chung, MD/PhD" schrieb:

    Quoted message said:


    Joe Smigiel wrote:


    [...]

    Quoted message said:
    Quoted message said:

    and helped prevent some weight loss. I could do fewer
    carbs...)

    Carbs don't cause obesity.

    A growing number of scientists will disagree with you on that. However
    that may be, cutting out most carbs will cause a vast majority of obese
    people to lose weight. In addition, it offers a whole host of other
    health benefits like reduced bloodpressure and lower triglcerides. If
    you are interested in how this works, I'd recommend the book "Protein
    Power" by Michael and Mary Eades to you.

    Thorsten

    I'll agree with you that cutting out refined carbohydrates is a good thing,
    but complex carbohydrates serve a very important nutritional function.

    I eat lots of complex carbs and I'm 5'7 3/4" tall without shoes and weigh
    131 pounds before breakfast, and, my triglyceride level is 65. Blood
    pressure at last reading was 118/70.

    Mel

  19. John Merlano said:
    MD/PhD said:
    Joe Smigiel said:

    I had a heart attack June 9th, 3xCABG on June 13th, and am feeling
    pretty good now. I'm 49 and male with a history of CAD in my family
    (older brother 5xCABG, father 3XCABG, paternal uncles all with MIs,
    CAD). I went through a hospital cardiac rehab regimen in about 4 weeks
    time this summer and have increased my exercise rate about 25-30% since
    graduating from the program.

    My cardiologist has me on Lipitor 10mg/day as well as metaprolol,
    Altace, aspirin, and a daily multivitamin. The last time checked &
    several years before the heart attack my cholesterol was 202. Last
    month it was 116 with the hdl/ldl ratio about 3.5.

    You probably mean LDL/HDL ratio.

    Quoted message said:

    Yesterday I had
    another blood test and the total cholesterol was less than 100, hdl @
    27. (Glucose 88, BP 90/58 which was low, usually around 100/70.)

    Your HDL needs to be higher. More exercise should help that.

    Quoted message said:


    Since surgery I've done some lifestyle changes including quitting
    smoking (was 1 1/2 packs per day for 32 years),

    Good.

    Quoted message said:

    continuing to exercise
    5-6 times per week

    This needs to be aerobic for at least 30 minutes daily preferably before
    supper.

    Quoted message said:

    and I have changed my diet considerably. I'm eating
    oats instead of eggs for breakfast, probably have one meal with lean
    meat daily (usually chicken or lean pork) and try to do a vegetarian
    meal per day. I've switched to mostly non- or low-fat, low-salt foods
    and am doing more fruits, veggies, fish and nuts, olive oil. etc., and I
    haven't had a cup of regular coffee since the cardiac event. I'm still
    about a 20 pounds overweight (although not obese) even with the
    increased exercise and diet changes. I've been trying to shed the extra
    weight since April but have only lost about 8 pounds total. (I figure
    the exclusion of nicotine and caffeine have probably affected my
    metabolic rate

    This does more to increase appetite than to lower metabolic rate.

    Quoted message said:

    and helped prevent some weight loss. I could do fewer
    carbs...)

    Carbs don't cause obesity.

    Doesn't eating refined carbs contribute to gaining weight?

    John Merlano

    No.

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com

  20. Thorsten Schier said:

    "Dr. Andrew B. Chung, MD/PhD" schrieb:

    Quoted message said:


    Joe Smigiel wrote:


    [...]

    Quoted message said:
    Quoted message said:

    and helped prevent some weight loss. I could do fewer
    carbs...)

    Carbs don't cause obesity.

    A growing number of scientists will disagree with you on that.

    If that were true, it should be easy for you to cite research studies
    describing carbohydrates causing obesity.

    Please don't cite Dr. Atkins:

    (1) He's dead.

    (2) He wasn't a scientist. Being a diet guru was not the same.

    Quoted message said:

    However
    that may be, cutting out most carbs will cause a vast majority of obese
    people to lose weight.

    Cutting out anything will cause weight loss. Problem is that research
    studies indicate that such "dieting" has dismal long-term success rates..

    Quoted message said:

    In addition, it offers a whole host of other
    health benefits like reduced bloodpressure

    That happens from losing weight.

    Quoted message said:

    and lower triglcerides.

    This also happens largely from losing weight.

    Without carbohydrates, there will be hyperketonemia. This is not a good
    thing physiologically.

    Quoted message said:

    If
    you are interested in how this works, I'd recommend the book "Protein
    Power" by Michael and Mary Eades to you.

    I prefer peer-reviewed journal article to books like "Protein Power."

    The latter sounds too much like "White Power."

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com

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