I have suffered from MAJOR saddle sores. The sore wouldent heal because it was on the crease inbetween my leg and my private area. Come to find out, after going on a century ride, my seat was tilted to the side ever so slightly, causing alot of pressure on that area. Which, resulted in a boil. I had tried EVERY remedy I could think of to heal it, none in which worked. I ultimatly had to go to my doctor, who prescribed antibiotics, and a cream to apply. That was the ONLY thing that worked for me. The doctor told me not to let any saddle sores "go" when they are bothersome and will not heal up, because it can result in a staff infection, and then it gets pretty serious. It sucked.